Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

By Eduard Hergenreider, S. Heydt, K. Tréguer, T. Boettger, A. Horrevoets, A. Zeiher, M. Scheffer, A. Frangakis, X. Yin, M. Mayr and 4 more. Nature Cell Biology, 2012

1,298 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ba81584294cf8842217cb908bcc78ce9abd79f77

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Citations in the corpus

Biological properties of extracellular vesicles and their physiological functions (2015, background): “In turn, EC-derived EVs transferred miR-143 and miR-145 to smooth muscle cells, inducing an atheroprotective phenotype (212).”
Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. (2015, background): “When exosomes derived from endothelial cells overexpressing KLF2, but not those from mock controls, were delivered into ApoE−/− mice, the mice were protected against high-fat diet–induced atherosclerosis, demonstrating that exosome-mediated transfer of miRNAs such as miR-143/145 is not just an in vi”
Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology (2017, background): “(C) During capillary invasion into the myocardium, a subset of the capillary bed develops into coronary arteries, which are covered by pericytes that differentiate into smooth muscle cells (SMCs).”
An overview of microRNAs (2015, background): “miRNAs can be taken up by target cells and mediate target gene repression[228-230].”
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis (2016, positive): “In addition, the expression of KLF2 was found to regulate other endothelial cell functions important for atherogenesis, including endothelial barrier function,(170) metabolism,(171) and the release of micro-RNAs (miRNAs) via the shedding of endothelial microvesicles.(172) Endothelial KLF2 expression”
Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “HUVECs-derived exosomes transported these miRNAs to smooth muscle cells (SMCs) which resulted in controlled target gene expression and reduction of atherosclerotic lesion formation in the mouse aorta [79].”
SORTING IT OUT: REGULATION OF EXOSOME LOADING (2014, background): “The transfer of RNA-loaded vesicles plays a key role in cell-cell communication in many different contexts and pathologies [3-6, 30, 57].”
Biodistribution and Delivery Efficiency of Unmodified Tumor-Derived Exosomes (2014, background): “The growing evidence of exosomes' innate ability to deliver naturally incorporated cargo to recipient cells has excited the drug delivery field [1–11].”
Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy (2014, background): “Exosomes transfer proteins and RNA (Lugini et al., 2012), notably microRNAs (miRNAs) (Zhu and Fan, 2011), from cell to cell, rationalizing potential applications in clinical therapeutics (Arslan et al., 2013; Hergenreider et al., 2012; O’Loughlin et al., 2012).”