Exosomes: extracellular organelles important in intercellular communication.

By Suresh Mathivanan, H. Ji, Richard J. Simpson. Journal of Proteomics, 2010

2,381 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f3f53d508f43ee5e372fb8fe342a4bc3b3257ee6

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Citations in the corpus

MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles (2013, positive): “Increasing evidence indicates that exosomes play an important role in cell-to-cell communication [28-32].”
CANCER-ASSOCIATED FIBROBLAST EXOSOMES REGULATE SURVIVAL AND PROLIFERATION OF PANCREATIC CANCER CELLS (2016, positive): “Recent studies have shown that exosomes, secreted membrane vesicles that range in size from 30–100 nm in diameter (10, 11), released from fibroblasts have been found to increase invasive behavior (12) and therapy resistance pathways (13) in breast cancer cells.”
ExoCarta as a resource for exosomal research (2012, methodology): “…of multivesicular bodies (MVBs) with the plasma membrane (PM), exosomes are of 40 (cid:2) 100 nm in diameter, are of endocytic origin, have a cup shaped appearance as visioned by electron microscopy, have a buoyant density in sucrose of 1.10 (cid:2) 1.21 g/mL and sediment at 100,000 g (9,10).”
Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. (2013, background): “While all these exosomes share an evolutionary conserved set of proteins molecules including tetraspanins (CD81, CD63, CD9), Alix and Tsg101 suggesting that they also share similar biological activities, they also have unique tissue/cell type-specific proteins that reflect their cellular source orig”
Exosome Theranostics: Biology and Translational Medicine (2018, background): “Apoptotic bodies and microvesicles are generated from the plasma membrane by direct budding and exist in a broad range of dimensions (apoptotic bodies, 800–5000 nm; microvesicles, 200–1000 nm [24, 25]), whereas exosomes are vesicles of endocytic origin with a diameter of 30–150 nm [26-28].”
Physiology of Astroglia. (2018, neutral): “Exosomes are formed intracellularly from multivesicular bodies (1083), whereas ectosomes are produced through direct budding of the plasma membrane (1744).”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “Heat shock proteins (Hsp), CD63 and tetraspanins are the most prominent evolutionary conserved proteins in exosomes [49].”
Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction. (2014, background): “Exosomes are 40–90 nm-sized particles stored intracellularly in endosomal compartments, which are secreted when these structures fuse with the plasma membrane.(12,13) Conventional surface markers of exosomes include the tetraspanin family members, CD9, CD63, and CD81, among others.”
Isolation of Extracellular Vesicles: General Methodologies and Latest Trends (2018, background): “Microvesicles (MVs) are membrane-covered vesicles of various shapes and a diameter of 50 to 1000 nm and more [16] and are formed by budding from the plasma membrane [13, 22].”
ExoCarta: A web-based compendium of exosomal cargo (2015, neutral): “Exosomes are small (30-150 nm) membranous vesicles secreted by a variety of cells into the extracellular microenvironment [1, 2].”
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, positive): “by direct budding from the plasma membrane (16,23).”