Exosomes--vesicular carriers for intercellular communication.

By M. Simons, G. Raposo. Current Opinion in Cell Biology, 2009

2,265 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d9c51101bd2ffebe914e35dde6a8f87016b788cd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Raposo
2. Raghu Kalluri
3. Hina Kalra
4. Suresh Mathivanan
5. Asfar S. Azmi
6. Fazlul H. Sarkar
7. Bin Bao
8. Richard J. Simpson

In Molecular Biology

1. G. Raposo
2. Suresh Mathivanan
3. Richard J. Simpson
4. C. Théry
5. Raghu Kalluri
6. Hina Kalra
7. Asfar S. Azmi
8. Fazlul H. Sarkar

Citations in the corpus

• Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016, background): “Exosomes are known to carry a complex cargo that includes proteins, lipids, and miRNAs (CostaSilva et al., 2015; Simons and Raposo, 2009).”
• Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “Additionally, the protein families that are associated with lipid microdomains, such as integrins and tetraspanins, such as CD9, CD81, CD82, CD83, and CD63 are also important part of exosome [48].”
• Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “Regarding their biochemical composition, exosomes are surrounded by a phospholipid membrane containing relatively high levels of cholesterol, sphingomyelin, and ceramide and containing detergent-resistant membrane domains (lipid rafts) (Wubbolts et al., 2003; Simons and Raposo, 2009; Théry et al., 2”
• Endosome maturation (2011, background): “They are released when LEs fuse with the plasma membrane (Simons and Raposo, 2009; Von Bartheld and Altick, 2011).”
• Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. (2014, background): “involvement in the immune response [51,52], but the characterization of exosomes as vectors of mRNA and microRNA [53,54] has boosted the field.”
• Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, background): “They can also be identified by the presence of proteins common to most exosomes, such as the tetraspanin proteins CD63, CD9, and CD81 [1–3].”
• Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “Most importantly, the aforementioned tetraspanins (enriched in exosomes) [2] and the small RAB GTPases (e.”
• Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol (2015, methodology): “The preferential method to adjust the centrifugation protocol to a specific rotor consists of selecting the proper centrifugation duration t* for the definite cut-off size of sedimented particles d* on the basis of equations (4, 16, 20, 21).”
• Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, neutral): “In the literature, exosomes are often described as smaller than 100 nm in diameter, while microvesicles are considered to be larger than 100 nm (7,16,24).”