Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

By Y. Loo, Jamie L. Fornek, N. Crochet, Gagan Bajwa, Olivia Perwitasari, L. Martínez-Sobrido, Shizuo Akira, M. Gill, A. García‐Sastre, Michael G. Katze and 1 more. Journal of Virology, 2007

1,098 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/8f927efbc9c066f5b3963081fa2f34d7d885cfad

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Citations in the corpus

Into the Eye of the Cytokine Storm (2012, background): “RIG-I-deficient cells show reduced expression of IFN- and genes as well as IFN-stimulated genes during influenza virus infection (91).”
Cytosolic Sensing of Viruses (2013, background): “Picornaviridae have come up with a more dramatic strategy: they trigger MDA5 and RIG-I cleavage and degradation by using the cell’s caspase and proteasome machinery and the viral protease 3Cpro (Barral et al., 2007; 2009).”
mRNA capping: biological functions and applications (2016, background): “Cytoplasmic pattern recognition receptors (PRRs) RIGI and RIG-I-like receptor MDA5 are sensors that trigger cellular type I interferon (IFN) response to virus infections (65).”
Recognition of 5′-triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative strand virus (2009, positive): “However, at first sight, this seemed less clear for RIG-I-mediated detection of negative single strand RNA viruses (Kato et al., 2006; Loo et al., 2008) for which no double-stranded RNA can be detected (Pichlmair et al.”
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, background): “Ce viruses, analysis of infected RIG-I / or MDA5 / cells illustrated the essential role of RIG-I in initiating antiviral responses against these RNA viruses (Loo et al., 2008).”
Influenza A Virus Panhandle Structure Is Directly Involved in RIG-I Activation and Interferon Induction (2015, background): “The indispensable role of RIG-I in IFN response to IAV infection has long been observed (1, 51); however, the nature of the RIG-I ligands from IAV is not well understood.”
Pathogen Recognition by the Innate Immune System (2011, background): “MDA5 recognizes members of the picornaviridae family, such as the Polio Virus and encephalomyocarditis virus (EMCV) (Table II) [48, 49].”
Innate Immunity to Virus Infection (2009, background): “However, Dengue virus and West Nile virus, which also belong to the Flaviviridae family, were shown to induce type I IFN production, even in the absence of RIG-I or MDA5 (20, 21).”
RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “Activated RIG-I and MDA5 are predicted to interact with IPS-1 via CARD–CARD interaction, which induces the recruitment of downstream signaling molecules (Fig.”
Peroxisomes are signaling platforms for antiviral innate immunity (2010, positive): “See also Figure S2. both RIG-I and MDA-5 signaling pathways (Loo et al., 2008), allowing direct examination of both RLRs in a single experiment.”
Immune signaling by RIG-I-like receptors (2011, background): “In contrast, NLRC5, another member of the NOD-like protein family, interacts with RIG-I and MDA5 but not IPS-1 to inhibit RLR-mediated IFN responses (Cui et al., 2010).”