Cytosolic Sensing of Viruses
By D. Goubau, Safia Deddouche, C. Reis e Sousa. Immunity, 2013
833 citations recorded by the source corpus.
Cells are equipped with mechanisms that allow them to rapidly detect and respond to viruses. These defense mechanisms rely partly on receptors that monitor the cytosol for the presence of atypical nucleic acids associated with virus infection. RIG-I-like receptors detect RNA molecules that are absent from the uninfected host. DNA receptors alert the cell to the abnormal presence of that nucleic acid in the cytosol. Signaling by RNA and DNA receptors results in the induction of restriction factors that prevent virus replication and establish cell-intrinsic antiviral immunity. In light of these formidable obstacles, viruses have evolved mechanisms of evasion, masking nucleic acid structures recognized by the host, sequestering themselves away from the cytosol or targeting host sensors, and signaling adaptors for deactivation or degradation. Here, we detail recent advances in the molecular understanding of cytosolic nucleic acid detection and its evasion by viruses.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e46ac4a04513f8f4b6d04e954f6faebb34990dbd
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In Immunology
In Molecular Biology
Citations in the corpus
- ATP-dependent effector-like functions of RIG-I like receptors (2015, background): “Consistent with their reported divergence in viral specificity (Goubau et al., 2013; Kato et al., 2011), full-length RIG-I and MDA5 suppressed different families of RNA viruses (Figure 4A).”