Influenza A Virus Panhandle Structure Is Directly Involved in RIG-I Activation and Interferon Induction

By Guanqun Liu, Hong-Su Park, Hyun-Mi Pyo, Qiang Liu, Yan Zhou. 2015

105 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Wenshuai Wang
2. A. García‐Sastre
3. Anna Marie Pyle

In Immunology

1. Wenshuai Wang
2. Anna Marie Pyle
3. A. García‐Sastre
4. V. Hornung
5. G. Hartmann
6. K. Hopfner
7. Zhijian J. Chen

Citations in the corpus

• The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands (2022, positive): “Although these dsRNAs can be of any length, short dsRNAs (10–20 base pairs), such as those found in a genomic viral RNA panhandle, are particularly potent RIG-I agonists (Kohlway et al., 2013; Linehan et al., 2018; Liu et al., 2015).”
• ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA (2015, background): “…2009; Schmidt et al., 2009) and not 2’ OH methylated at the first 5’ terminal nucleotide (Schuberth-Wagner et al., 2015). ppp-dsRNA arises, for example, at panhandle structures of influenza virus nucleocapsids, or during measles or Sendai virus transcription (Liu et al., 2015; Weber et al., 2013).”
• Recent advances in RNA structurome (2022, background): “The panhandle structure not only promotes the initiation of IAV transcription (Fodor et al., 1994), but also binds and activates RIG-I (Figure 5E) (Liu et al., 2015).”