AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

By Sibylle Jäger, Christoph Handschin, J. St-Pierre, B. Spiegelman. Proceedings of the National Academy of Sciences of the United States of America, 2007

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How researchers see this paper

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AMPK - a nutrient and energy sensor that maintains energy homeostasis (2012, background): “AMPK directly phosphorylates PGC1α, which has been proposed to cause activation of its own transcription via a positive feedback loo”
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “67 Another important post-translational modiﬁcation of PGC-1 a is the deacetylation induced by the NAD þ -dependent SIRT1 deacetylase.”
Integrative biology of exercise. (2014, positive): “…a highly sensitive, complex transduction network. induces mitochondrial biogenesis partly by directly phosphory-lating and activating PGC-1 a (Ja¨ger et al., 2007), but also by phosphorylating the transcriptional repressor HDAC5, which relieves inhibition of the transcription factor myocyte…”
The role of exercise and PGC1α in inflammation and chronic disease (2008, background): “The multifaceted interaction of PGC1α with AMP-activated protein kinase is likely to be important for modulating these metabolic fluxe”
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011, background): “AMPK has been reported to directly phosphorylate PGC-1a at two sites (although neither is a good fit to the AMPK recognition motif described above), and this is proposed to activate transcription of PGC-1a from its own promoter via a positive feedback loop (Jager et al. 2007).”