The role of exercise and PGC1α in inflammation and chronic disease

By Christoph Handschin, B. Spiegelman. Nature, 2008

1,018 citations recorded by the source corpus.

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

Subfields: Epidemiology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/4c981d0d566d1702bab0932ee1a13709c12590d2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Physiology

In Rehabilitation

Citations in the corpus

Muscles and their myokines (2011, background): “…the health consequences of abdominal adiposity and physical inactivity are similar and both physical inactivity (Pedersen and Febbraio, 2008) and abdominal adiposity (Yudkin, 2007) are associated with persistent systemic low-grade inflammation (Festa et al., 2002; Handschin and Spiegelman, 2008).”
The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk (2009, background): “Exercise increases the release of adrenaline, cortisol, growth hormone, prolactin and other factors that have immunomodulatory effects (Nieman, 2003; Handschin & Spiegelman, 2008).”
Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms (2011, background): “Ghanim et al. (2004); Handschin and Spiegelman (2008); Hotamisligil (2006); Kiecolt-Glaser (2010); O’Connor et al. (2009); Yanbaeva et al. (2007); Yudkin et al. (2000)”
The Mitochondrial Basis of Aging (2016, background): “Mitochondrial biogenesis is largely coordinated by the transcriptional coactivator peroxisome proliferator-activated receptor g coactivator-1 a (PGC1a) (Handschin and Spiegelman, 2008; Ruas et al., 2012).”
A PGC1α-dependent myokine that drives browning of white fat and thermogenesis (2012, background): “PGC1-a is induced in muscle by exercise and stimulates many of the best-known beneficial effects of exercise in muscle: mitochondrial biogenesis, angiogenesis and fibre-type switchin”
Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase (2009, background): “Indeed, myokines are now recognised as a major contributing factor that links muscular activity with health [13].”
Exercise–induced BCL2–regulated autophagy is required for muscle glucose homeostasis (2012, background): “ppt"/> Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabete”
FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine (2013, background): “More recently, it was shown that PGC1a is induced in muscle by exercise stimulating several of the beneficial effects of exercise in this tissue [10].”
Knee osteoarthritis has doubled in prevalence since the mid-20th century (2017, background): “Chronic low-grade inflammation, which is exacerbated by physical inactivity (37), modern diets rich in highly refined carbohydrates (38), and excessive adiposity (10), can further magnify and accelerate loading-induced damage to joint tissues and may also directly affect knee OA pathogenesis (5).”