Hypocretin (orexin) deficiency in human narcolepsy.

By S. Nishino, B. Ripley, S. Overeem, G. Lammers, E. Mignot. The Lancet, 2000

1,732 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/8d9611363739f3c207e012c40d9e65f49619a8d7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. T. Sakurai
2. J. Allan Hobson
3. J. Siegel
4. E. Pace-Schott
5. T. Scammell
6. H. Haas
7. Clifford B. Saper
8. P. Goadsby

In Endocrine and Autonomic Systems

1. T. Sakurai
2. J. Allan Hobson
3. J. Siegel
4. E. Pace-Schott
5. Clifford B. Saper
6. T. Scammell
7. Joseph E LeDoux
8. Matthew P. Walker

In Experimental and Cognitive Psychology

1. T. Sakurai
2. J. Allan Hobson
3. J. Siegel
4. T. Scammell
5. E. Pace-Schott
6. Clifford B. Saper
7. Matthew P. Walker
8. Robert Stickgold

Citations in the corpus

• The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness (2007, result): “This supports earlier reports that orexin A was undetectable in the cerebrospinal fluid of narcolepsy patient”
• Differential expression of orexin receptors 1 and 2 in the rat brain (2001, neutral): “Scale bar 5 1 mm. brospinal fluid (Nishino et al., 2000).”
• Fos Expression in Orexin Neurons Varies with Behavioral State (2001, background): “, 2000), and individuals with narcolepsy often have unmeasurably low orexin levels in CSF (Nishino et al., 2000).”
• A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains (2000, background): “Recent publications have implicated the hypocretin system in sleep regulation and narcoleps”
• The role of histamine and the tuberomamillary nucleus in the nervous system (2003, background): “The orexin neurons, the absence of which leads to narcolepsy — a severe disturbance of slee”
• Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “It has been reported that deficiency in orexin neurotransmission results in the sleep disorder narcolepsy in mice, dogs, and humans (161, 532, 628, 778), and one aspect of orexin activity is the direct excitation of noradrenergic neurons in the LC to promote wakefulness (117, 416).”
• The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. (2002, result): “Of note, we did not confirm our finding of high hypocretin-1 (extracted 500 pg/mL) values in narcolepsy.(25,26) In this extended series, high values were also observed in nonnarcoleptic subjects.”
• To eat or to sleep? Orexin in the regulation of feeding and wakefulness. (2001, background): “Nishino et al (2000) found that orexin-A was undetected in the cerebrospinal fluid (CSF) of 7 of 9 narcoleptic patients, but readily and consistently detected in normal controls.”
• The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks (2002, background): “and a deficiency of orexin in the cerebrospinal flui”
• Reduced Number of Hypocretin Clinical Study Neurons in Human Narcolepsy (2000, positive): “The greatly reduced numbers of Hcrt neurons can also explain the reduced levels of Hcrt reported in the cerebrospinal fluid of narcoleptics (Nishino et al., 2000).”