The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

By T. Sakurai. Nature Reviews Neuroscience, 2007

1,237 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/9c4f4e8a6db3ea98fadad5a9fd4b917179cd8dea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. P. Goadsby
2. J. Takahashi
3. C. Varela

In Endocrine and Autonomic Systems

1. J. Takahashi
2. C. H. Ko
3. Erin L. McDearmon
4. C. Varela
5. Heekyung Hong

In Experimental and Cognitive Psychology

1. J. Takahashi
2. Kenneth P. Wright Jr.
3. C. Varela

Citations in the corpus

• Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “Orexins A and B are hypothalamic neuropeptides that are made solely in hypothalamic nuclei, including the posterior hypothalamic region (356), and are involved in the hypothalamic regulation of sleep, feeding, and arousal and the autonomic system (405, 700, 802).”
• The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “That is, can we find genes that selectively regulate sleep homeostasis independently of circadian rhythms and vice versa? Perhaps the only known genes that are definitively associated with sleep independent of the circadian system thus far are those genes causing narcolepsy , in which the loss of h”
• Thalamic neuromodulation and its implications for executive networks (2014, background): “In fact, the paraventricular is the thalamic nucleus with the densest orexinergic innervation (Sakurai, 2007), and the effect of these peptides on paraventricular networks deserves further investigation.”
• PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. (2008, neutral): “The heart of the mammalian sleep circuit is a switch consisting of reciprocally connected sleep and arousal centers (Fuller et al., 2006; Sakurai, 2007).”
• Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain (2013, background): “For example, orexin/hypocretin levels increase during sleep loss (39) and orexin/hypocretin neurons are an important component of sleep–wakefulness and feeding neural systems (40, 41).”
• General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal (2008, neutral): “Orexins (A and B) are small peptides that are released exclusively from the lateral hypothalamus, particularly the perifornical area, and defects in this system are thought to have a pivotal role in narcoleps”
• Effects of poor and short sleep on glucose metabolism and obesity risk (2009, neutral): “Orexin-containing neurons have a central role in the maintenance of arousal, but also increase food intake”