Differential expression of orexin receptors 1 and 2 in the rat brain

By Jacob N. Marcus, Carl J. Aschkenasi, Charlotte E. Lee, R. Chemelli, Clifford B. Saper, M. Yanagisawa, J. Elmquist. The Journal of comparative neurology, 2001

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The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness (2007, background): “The distribution of mRNA for the orexin receptors is consistent with these projection sites; within the brain, OX 1 R mRNA is most abundantly expressed in the LC, whereas OX 2 R mRNA is highly expressed in the TM”
Expression of ghrelin receptor mRNA in the rat and the mouse brain (2006, methodology): “Single-label ISHH Single-label ISHH was performed as reported previously by our laboratory (Marcus et al., 2001; Kishi et al., 2003).”
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. (2003, background): “Both receptors are expressed in nuclei of the hypothalamus and MPT as well as more widespread Results regions of the central nervous system (Marcus et al., 2001).”
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. (2006, positive): “Single-label in situ hybridization histochemistry (ISHH) was performed as reported previously (Kishi et al., 2003; Marcus et al., 2001 ).”