Reduced Number of Hypocretin Clinical Study Neurons in Human Narcolepsy

By Thomas C. Thannickal, R. Moore, R. Nienhuis, Lalini Ramanathan, S. Gulyani, M. Aldrich, M. Cornford, J. Siegel. 2000

1,878 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f65610116165ff751d49ef80f39f144ea49f751d

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Citations in the corpus

Hypothalamic regulation of sleep and circadian rhythms (2005, background): “The following year, it was reported that humans who have narcolepsy with cataplexy have few orexin neurons in the LHA and low orexin levels in the cerebrospinal flui”
Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy (2017, unknown): “an overlap of 0.25 seconds was selected. Scaling: As with the octave decomposition, the data is scaled, although only within segments: 𝐷𝐷𝑖𝑖= 𝛾𝛾𝑥𝑥 𝑖𝑖𝑦𝑦𝑖𝑖∙log(1 + max(�𝛾𝛾𝑥𝑥 𝑖𝑖𝑦𝑦𝑖𝑖�) max(|𝛾𝛾𝑥𝑥 𝑖𝑖𝑦𝑦𝑖𝑖 |) (3) where 𝐷𝐷𝑖𝑖is the scaled correlation function and 𝛾𝛾𝑥𝑥 ”
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. (2002, background): “A selective loss of hypocretin messenger RNA (mRNA) and immunoreactivity has also been reported in the hypothalamus of 6 patients.(29,30) Together with the HLA association, these results suggest that most human cases are caused by an autoimmune-mediated destruction of hypocretin neurons.”
Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle (2005, background): “Yet, loss of the peptide orexin (Orx) (also called hypocretin), its receptor, or the neurons that contain it, results in an incapacity to maintain wakefulness and a syndrome known as narcolepsy, characterized by hypersomnolence, sudden onset of rapid eye movement sleep (REMS) [also called paradoxica”
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks (2002, background): “Interestingly, human narcoleptics show a large reduction in the number of orexinergic neurons in the lateral hypothalamu”
Sleep (2007, background): “Many of the symptoms of narcolepsy can be mimicked by genetic deletion of the hypocretin or Orexin peptide in mice (Chemelli et al., 1999) or the mutation of the hypocretin or Orexin receptor2 gene in the dog (Lin et al., 1999).”
Fos Expression in Orexin Neurons Varies with Behavioral State (2001, background): “The brains of narcoleptics exhibit a nearly complete loss of neurons expressing orexin mRNA or peptide (Peyron et al., 2000; Thannickal et al., 2000), and individuals with narcolepsy often have unmeasurably low orexin levels in CSF (Nishino et al., 2000).”
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. (2003, background): “…on bayashi et al., 2002; Mignot et al., 2002a; Peyron et whole-brain homogenates failed to detect significant al., 2000; Ripley et al., 2001b; Thannickal et al., 2000). changes in the amounts of these peptides in OX2R / Furthermore, detection of extracellular orexin peptide mice compared to…”