Fos Expression in Orexin Neurons Varies with Behavioral State

By I. Estabrooke, Marie T. McCarthy, E. Ko, T. Chou, R. Chemelli, M. Yanagisawa, Clifford B. Saper, T. Scammell. Journal of Neuroscience, 2001

679 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/6af4f2247d285b3776026314cb5604f4822398c3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. T. Sakurai
2. T. Scammell
3. E. van Cauter
4. J. Siegel
5. K. Spiegel
6. Jun Lu
7. Clifford B. Saper
8. P. Goadsby

In Endocrine and Autonomic Systems

1. T. Sakurai
2. T. Scammell
3. J. Siegel
4. E. van Cauter
5. Jun Lu
6. Clifford B. Saper
7. K. Spiegel
8. Rachel Leproult

In Experimental and Cognitive Psychology

1. T. Sakurai
2. T. Scammell
3. J. Siegel
4. E. van Cauter
5. Jun Lu
6. K. Spiegel
7. Clifford B. Saper
8. Rachel Leproult

Citations in the corpus

• Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “Hypothalamic orexin levels are highest during wakefulness and lowest during sleep (258, 469), with almost total cessation during REM periods, in vivo (521).”
• Behavioral correlates of activity in identified hypocretin/orexin neurons. (2005, positive): “Estabrooke et al. (2001) reported that c-Fos immunoreactivity in Hcrt cells in rats was elevated in waking and was reduced during periods containing both slow wave (SW) and rapid eye movement (REM) sleep, suggesting that Hcrt cellular activity was minimal at these times.”
• Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle (2005, background): “Similarly, studies assessing Orx neuronal activity by examining c-Fos expression have indicated that it was high with waking (W) (Estabrooke et al., 2001) yet also appeared to be high during pharmacologically induced REMS (Torterolo et al.”
• Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. (2004, background): “Recent rodent studies have indicated that hypocretin neuronal activity and hypocretin-1 release are stimulated by sleep deprivation (14, 15).”
• Sleep State Switching (2010, background): “In normal animals, the orexin neurons are active during wakefulness, especially during active exploration of the environment (Estabrooke et al., 2001; Lee et al., 2005; Mileykovskiy et al., 2005), and they provide excitatory tone to wake-promoting monoaminergic and cholinergic cell groups.”
• The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness (2007, background): “Consistent with this idea, Fos expression (a marker of neuronal activity) in orexin neurons in rats is increased during the dark, active period in which the awake state is dominan”
• Hypothalamic regulation of sleep and circadian rhythms (2005, background): “Orexin neurons in the LHA are, similarly, most active during wakefulnes”
• Effects of poor and short sleep on glucose metabolism and obesity risk (2009, neutral): “Increased orexin activity during periods of sleep deprivation has been shown in rats, dogs and squirrel monkeys”
• Pathophysiology of sleep apnea. (2010, background): “Orexinergic neurons project to both trigeminal and hypoglossal motoneuronal soma and dendrites (180), and these neurons, like the monoaminergic groups, have reduced c-fos activation in NREM and REM sleep (157); however, like ACh, levels of orexin in motor nuclei are greatest in wake and REM sleep (3”
• General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal (2008, neutral): “Neuronal firing and c-fos expression in orexinergic neurons is high during wakefulness compared with during NREM or REM slee”