To eat or to sleep? Orexin in the regulation of feeding and wakefulness.

By J. Willie, R. Chemelli, C. Sinton, Masashi Yanagisawa. Annual Review of Neuroscience, 2001

759 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/ffc214487ed0983d1fab49e113735544e8354e76

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Endocrine and Autonomic Systems

In Experimental and Cognitive Psychology

Citations in the corpus

Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. (2003, background): “…of histaminergic neurons in the in the hypothalamus as a critical participant in sleep/ hypothalamus, which gate non-REM sleep onset. wake control (Mignot et al., 2002b; Saper et al., 2001; While normal regulation of wake/non-REM sleep tran- Sutcliffe and de Lecea, 2002; Willie et al., 2001).”
Multiple neural systems controlling food intake and body weight. (2002, background): “It was thus suggested that this peptide signaling system plays a significant role in feeding and sleep– wakefulness, possibly by coordinating the complex behavioral and physiologic/autonomic responses of these complementary homeostatic functions [213,268].”
Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption (2017, background): “The orexigenic neuropeptides orexin-1 and 2 (also known as hypocretin-1 and 2) for example not only centrally stimulate food intake but also exert wake-promoting effects [170].”
Histamine in the nervous system. (2008, background): “Hypocretin neurons (136, 820) activate the aminergic wakepromoting nuclei (83, 163, 366, 661) and are crucial for behavioral state bistability (636).”
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness (2007, background): “Furthermore, whereas OX 1 R -knockout mice show only a mild fragmentation of sleep and awake state”
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice (2005, methodology): “For this analysis, we focused on the orexin transcript, because the orexinergic system is involved in both feeding and sleep-wake regulation [14, 15].”