Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

By Jenny Mjösberg, S. Trifari, N. Crellin, C. Peters, C. Drunen, Berber Piet, W. Fokkens, T. Cupedo, H. Spits. Nature Immunology, 2011

1,142 citations recorded by the source corpus.

Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22)- and IL-17-producing ILCs, which depend on the transcription factor RORγt, express CD127 (IL-7 receptor α-chain) and the natural killer cell marker CD161. Here we describe another lineage-negative CD127+CD161+ ILC population found in humans that expressed the chemoattractant receptor CRTH2. These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13. CRTH2+ ILCs were present in fetal and adult lung and gut. In fetal gut, these cells expressed IL-13 but not IL-17 or IL-22. There was enrichment for CRTH2+ ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 (TH2) cytokines.

Subfields: Emergency Medical Services, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/8be7101d895af08a325fe640ee0af29ab330c8f5

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Citations in the corpus

Innate lymphoid cells and asthma. (2014, positive): “Finally, ILC2s have been found in nasal polyp tissue from patients with chronic rhinosinusitis.(58) Because TSLP levels are increased in nasal polyps of patients with chronic rhinosinusitis(62) and because IL-33 and ST2 are increased in the serum and tissue of patients with allergic rhinitis,(63) IL”
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages (2013, background): “…source of these cyto kines, and loss of these cells can compromise the host type 2 immune response (Brickshawana et al., 2011; Chang et al., 2011; Mjösberg et al., 2011; Moro et al., 2010; Neill et al., 2010; Price et al., 2010; Halim et al., 2012; Ikutani et al., 2012; infection in mice and…”
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. (2012, positive): “These cells express CD127, the prostaglandin D2 receptor, chemoattractant receptor expressed on Th2 cells (CRTH2), and the common ILC and NK cell marker CD161 (Mjösberg et al., 2011).”
A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis (2013, background): “Several recent studies have identified a family of CD45-expressing hematopoietic effector ILCs that link the innate and adaptive arms of the immune system (Mjösberg et al., 2011; Spits and Cupedo, 2012; Walker et al., 2013).”
Innate Lymphoid Cells: a new paradigm in immunology (2015, background): “ILC2s and IL-13 are also associated with hepatic fibrosis induced in mice by thioacetamide, carbontetrachloride, and Schistosoma mansoni (109), and with pulmonary fibrosis (108), chronic rhinosinusitis (110), and atopic dermatitis (111, 112), as well as allergen- (112, 113) and rhinovirusinduced ast”