Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.

By Shimon Sakaguchi. Annual Review of Immunology, 2004

3,789 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8cefb044a37de23d93f337fd6f2bcad1c75a2863

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In Immunology

Citations in the corpus

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires (2006, background): “It is now recognized that these autoreactive T cells are normally kept in check by the presence of CD4 + regulatory T cells (T reg cells”
Nonredundant roles for Stat5a/b in directly regulating Foxp3. (2007, neutral): “by reconstitution with CD4CD25 T cells.(13) The essential role of Treg cells in”
Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System1 (2005, background): “Although the in vitro suppression by these cells did not appear to be IL-10 dependent, this is consistent with the main body of evidence on these cells: that IL-10 is not the mechanism of in vitro suppression but may be important in vivo in some models (11).”
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice (2007, background): “In contrast, depletion of T reg cells by neonatal thymectomy, by adoptive transfer of naive T cell samples depleted of T reg cells into lymphopenic hosts or by treatment of mice with antibodies specific for CD25, which is highly expressed on most T reg cells, results in a much milder and more slo”
Identification of IL-17-producing FOXP3+ regulatory T cells in humans (2009, background): “Although FOXP3 Treg cells are critical for control of autoimmunity and inflammation (34), Th17 cells have been implicated in mediating inflammation and autoimmune diseases (4).”
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans (2006, background): “On the contrary, natural CD4CD25 Tregs are selected in the thymus and thus have predefined antigen specificity (52, 53).”
Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma (2005, background): “Regulatory T-cell subsets Regulatory or suppressor T cells are cells that inhibit inflammatory pathologies in vivo , and they have also been shown to control T-cell proliferation and cell number in vitro and in vivo”