Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System1

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The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “During EAE, an accumulation of Tregs in the CNS has consistently been seen during disease resolution (129, 161, 165, 166).”
Mechanisms of foxp3+ T regulatory cell-mediated suppression. (2009, background): “However, multiple studies in vivo have shown that secretion of IL-10 by Treg cells constitutes an important component of their suppressive effects (Belkaid, 2007; McGeachy et al., 2005).”
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease (2006, background): “The animals that survived are frequently refractory to the secondary challenge with the same self-antigen, and this resistance can be overcome by depletion of natural Tregs before the secondary challenge, at least in certain EAE models (123).”
Inflammatory mechanisms in ischemic stroke: role of inflammatory cells (2010, unknown): “diseases [91–93].”
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. (2015, unknown): “There is also increasing evidence that Tregs may utilize metabolic strategies to suppress Teffs (33).”