WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

By B. Hobmayer, Fabian Rentzsch, K. Kuhn, C. Happel, Christoph Cramer von Laue, P. Snyder, U. Rothbächer, T. Holstein. Nature, 2000

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The Hedgehog and Wnt signalling pathways in cancer (2001, background): “One of the most striking effects of Wnt proteins is their ability to induce formation of a new embryonic axis in metazoans ranging from Hydra to Xenopus”
Neuropeptides in Cnidarians (2002, background): “Furthermore, many features that are characteristic of higher metazoans, such as patterning and axis formation during development, and the presence of a nervous system, were probably “invented” by cnidarians or a closely related ancestor group (Mackie 1990; Hobmayer et al. 2000; Bode 2001).”
Tissue repair and stem cell renewal in carcinogenesis (2004, background): “This may result either from normal asexual budding or from experimental manipulations, such as cell dissociation and re-aggregatio”
Unexpected complexity of the Wnt gene family in a sea anemone (2005, background): “vectensis Wnt genes reveal a thus far unpredicted ancestral diversity within the Wnt famil”
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. (2006, background): “2003), the diploblast Hydra (Hobmayer et al. 2000), and the sponge Oscarella carmela (Nichols et al.”