mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

By Chong Chen, Yu Liu, Yang Liu, P. Zheng. Science Signaling, 2009

667 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4996feec216fc05ee775a40ecf229b3b8f5d6b78

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Citations in the corpus

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. (2011, background): “A recent report (17) has also shown increased life span in aged mice exposed to rapamycin.”
mTOR Signaling in Growth, Metabolism, and Disease. (2017, background): “Finally, another model suggests that the attenuation of adult stem cells in various tissues plays a central role in organismal aging, and mTOR inhibition boosts the self-renewal capacity of both hematopoietic and intestinal stem cells in mice (Chen et al., 2009; Yilmaz et al., 2012).”
mTOR signaling in growth control and disease (2012, positive): “Chen et al. (2009) observed that old mice have elevated mTORC1 signaling in hematopoietic stem cells (HSC) and that induction of mTORC1 by Tsc1 loss induces premature aging in HSC. Importantly, reducing mTORC1 signaling with rapamycin restoresHSCself-renewal and hematopoietic function, improves…”
mTOR inhibition improves immune function in the elderly (2014, background): “In aged mice, mTOR inhibition also has been shown to increase the number of HSCs, leading to increased production of naïve lymphocytes (10).”
Autophagy and aging. (2011, background): “In old mice, rapamycin increases life span (Harrison et al., 2009) and simultaneously restores the self-renewal of hematopoietic stem cells (HSCs), thus improving the function of the immune system (Chen et al., 2009).”
Metabolic Plasticity in Stem Cell Homeostasis and Differentiation (2012, positive): “Such mitochondrial infrastructure is also characteristic of hematopoietic stem cells (HSCs) (Piccoli et al., 2005) and mesenchymal stem cells (MSCs) (Chen et al., 2008b; Lonergan et al., 2006), Cell Stem Cell 11, November 2, 2012 ª2012 Elsevier Inc. 597 Catabolic and anabolic pathways are interconne”
The hallmarks of aging. (2013, background): “In particular, mTORC1 inhibition with rapamycin, which can postpone aging by improving proteostasis (see ‘‘Loss of Proteostasis’’) and by affecting energy sensing (see ‘‘Deregulated Nutrient Sensing’’), may also improve stem cell function in the epidermis, in the hematopoietic system, and in the int”
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, positive): “,179 Other studies revealed that mTORC1 and SLC7A5 regulate the self-renewal of intestinal stem cell self-renewal and Paneth cell function in maintaining intestinal niche and physiology.”
mTOR Signaling in Growth, Metabolism, and Disease (2017, background): “Finally, another model suggests that the attenuation of adult stem cells in various tissues plays a central role in organismal aging, and mTOR inhibition boosts the self-renewal capacity of both hematopoietic and intestinal stem cells in mice (Chen et al., 2009; Yilmaz et al., 2012).”
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity (2012, background): “mechanistic (previously referred to as mammalian) target of rapamycin complex 1 (mTORC1) (2, 3).”
Metabolic Control of Longevity. (2016, background): “Curiously, and despite its anti-inflammatory and immunosuppressive properties, rapamycin can rejuvenate immune stem cell function (Chen et al., 2009).”