mTOR inhibition improves immune function in the elderly
By J. Mannick, G. Del Giudice, M. Lattanzi, N. Valiante, J. Praestgaard, Baisong Huang, M. Lonetto, Holden T. Maecker, J. Kovarik, Simon Carson and 2 more. Science Translational Medicine, 2014
716 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/467ab7a29224e9d1bdc87eb8c757b3daee2b2e19
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In Immunology
In Molecular Biology
- R. A. Saxton
- Jesús Gil
- Rajiv K. Tonk
- Vivek Panwar
- Manini Bhatt
- Shinjinee Sengupta
- Manoj Garg
- Aishwarya Singh
Citations in the corpus
- Cellular Senescence: A Translational Perspective (2017, background): “…impairment, and immune dysfunction in mouse models, and enhance antibody response to influenza vaccination in elderly humans, among other effects (Harrison et al., 2009; Li et al., 2014; Majumder et al., 2012; Wilkinson et al., 2012, Zhang et al., 2014, Mannick et al., 2014; Bitto et al., 2016).”
- mTOR Signaling in Growth, Metabolism, and Disease (2017, background): “There is reason for optimism, however, as a trial in healthy elderly humans using everolimus showed safety and even improved immune function (Mannick et al., 2014), and alternative dosing regimens have been proposed that can promote longevity with reduced side effects (Arriola Apelo et al., 2016).”
- Senescence and the SASP: many therapeutic avenues (2020, background): “The presence of DNA and other types of macromolecular damage ultimately leads to cessation of proliferation through activation of the p53/ p21CIP1 and p16INK4a/RB tumor suppressor pathways (McHugh and Gil 2018).”
- Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019, background): “The improved response after rapamycin treatment, whichmight involve a decrease in the percentage of PD-1 positive T cells, requires more detailed studies (207).”
- Measuring biological aging in humans: A quest (2019, background): “Accordingly, pretreatment with rapamycin analogs that inhibit TORC1 enhances immune function and reduces infections in the elderly (Mannick et al., 2014; Shavlakadze et al., 2018).”
- Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, background): “183,184 The low dosages of everolimus markedly decreased the rate of infections and enhanced the vaccination response against in fl uenza with increased antiviral immunity.”