mTOR Signaling in Growth, Metabolism, and Disease.

By R. A. Saxton, David M. Sabatini. Cell, 2017

3,725 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5efe2736b1a32fca53c6b4763f37afbfd0137df8

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Citations in the corpus

Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “It plays a key role in growth, metabolism, autophagy, and other biological processes.254 mTOR, which forms subunits of two protein complexes referred to as Signal Transduction and Targeted Therapy (2023) 8:56 mTOR Complex 1(mTORC1) and mTOR Complex 2 (mTORC2), belongs to the phosphatidylinositol 3-k”
Mitochondrial dysfunction: mechanisms and advances in therapy (2024, neutral): “116 Transcriptionally, mTOR controls the expression of mitochondrial genes (such as Cytochrome c , Atp5 g, and Cox5a ) by regulating the coactivation of yin-yang 1 (YY1) and PGC-1 α .”
C24‐Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5‐Phosphate 4‐Kinase Type‐2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation (2020, background): “Strikingly, the PI3K-AKT-mTOR pathway, MYC targets, and lipogenesis signaling were significantly compromised upon C6-Ceramide stimulation, suggesting that C6-Ceramide primarily targets PI3KAKT-mTOR signaling, a central regulator of energy metabolism through two major downstream effectors, S6K and 4E”
Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “mTORC1 integrates inputs from nutrient and growth signals to regulate general cellular processes such as protein and lipid synthesis, autophagy, and metabolism (Saxton and Sabatini, 2017).”
Metabolic reprogramming and cancer progression (2020, background): “Growth factor signaling and nutrient availability converge on mTOR complex-1 (mTORC1), which integrates these signals to stimulate ribosome biogenesis, protein synthesis, and other pathways required for cell growth (35).”
The PI3K pathway in human disease (2017, neutral): “mTORC1 also initiates powerful negative feedback regulation of growth factor receptor signaling, such that inhibition of mTORC1 or S6K1 leads to elevated activation of PI3K, AKT, and the ERK pathway (Carracedo et al., 2008; Saxton and Sabatini, 2017).”
Targeting PI3K/Akt signal transduction for cancer therapy (2021, background): “As a protein kinase, mTOR is considered an atypical member of the PI3K-related kinase family, and it is usually assembled into complexes, such as mTORC1 and mTOR complex 2 (mTORC2), to play critical roles in many biological processes.(79) Many growth factors and their receptors, such as VEGF and VEG”
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “As the primary regulator of cellular metabolism, mTOR can promote cell growth following various environmental cues.(127) mTOR forms two multiprotein complexes by binding with different companion proteins, namely mTORC1 and mTORC2.”
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “…in mediating ferroptosis under different conditions. mTOR signaling The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase, 218 is a key target in cancer research due to its involvement in the PI3K/AKT/mTOR signaling pathway, which is frequently activated in human cancers…”
Specificity, versatility and control of TGF-β family signaling (2019, background): “12, eaav5183 (2019) 26 February 2019 rylates and thus activates mTOR, which, among other responses, promotes protein synthesis and cell metabolism, is required for cell migration, and phosphorylates AKT in a positive feedback loop (311, 312).”