MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?
By E. Sonkoly, T. Wei, P. Janson, A. Sääf, L. Lundeberg, M. Tengvall-Linder, G. Norstedt, H. Alenius, B. Homey, A. Scheynius and 2 more. PLoS ONE, 2007
792 citations recorded by the source corpus.
MicroRNAs are a recently discovered class of posttranscriptional regulators of gene expression with critical functions in health and disease. Psoriasis is the most prevalent chronic inflammatory skin disease in adults, with a substantial negative impact on the patients' quality of life. Here we show for the first time that psoriasis-affected skin has a specific microRNA expression profile when compared with healthy human skin or with another chronic inflammatory skin disease, atopic eczema. Among the psoriasis-specific microRNAs, we identified leukocyte-derived microRNAs and one keratinocyte-derived microRNA, miR-203. In a panel of 21 different human organs and tissues, miR-203 showed a highly skin-specific expression profile. Among the cellular constituents of the skin, it was exclusively expressed by keratinocytes. The up-regulation of miR-203 in psoriatic plaques was concurrent with the down-regulation of an evolutionary conserved target of miR-203, suppressor of cytokine signaling 3 (SOCS-3), which is involved in inflammatory responses and keratinocyte functions. Our results suggest that microRNA deregulation is involved in the pathogenesis of psoriasis and contributes to the dysfunction of the cross talk between resident and infiltrating cells. Taken together, a new layer of regulatory mechanisms is involved in the pathogenesis of chronic inflammatory skin diseases.
Subfields: Cancer Research, Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/e330640f4be7eda8be142633eddd79b53d76ab5a
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
Citations in the corpus
- miRecords: an integrated resource for microRNA–target interactions (2008, background): “Indeed, it has become a common practice for experimental researchers to look at predictions made by several target prediction programs and focus on their intersections (30,31).”
- MicroRNAs in development and disease. (2011, background): “Surely, only in psoriasis, miR-203 targets SOCS-3, which is a negative regulator in cytokine signaling pathways and keratinocyte proliferation (372) and is downregulated in the psoriatic lesions (571).”