Immunology of Psoriasis

By M. Lowes, M. Suárez‐Fariñas, J. Krueger. Annual Review of Immunology, 2014

1,647 citations recorded by the source corpus.

The skin is the front line of defense against insult and injury and contains many epidermal and immune elements that comprise the skin-associated lymphoid tissue (SALT). The reaction of these components to injury allows an effective cutaneous response to restore homeostasis. Psoriasis vulgaris is the best-understood and most accessible human disease that is mediated by T cells and dendritic cells. Inflammatory myeloid dendritic cells release IL-23 and IL-12 to activate IL-17-producing T cells, Th1 cells, and Th22 cells to produce abundant psoriatic cytokines IL-17, IFN-γ, TNF, and IL-22. These cytokines mediate effects on keratinocytes to amplify psoriatic inflammation. Therapeutic studies with anticytokine antibodies have shown the importance of the key cytokines IL-23, TNF, and IL-17 in this process. We discuss the genetic background of psoriasis and its relationship to immune function, specifically genetic mutations, key PSORS loci, single nucleotide polymorphisms, and the skin transcriptome. The association between comorbidities and psoriasis is reviewed by correlating the skin transcriptome and serum proteins. Psoriasis-related cytokine-response pathways are considered in the context of the transcriptome of different mouse models. This approach offers a model for other inflammatory skin and autoimmune diseases.

Subfields: Dermatology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/1e54b0ecfeaecb78fd1761092c016a74db4617bd

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In Immunology

1. M. V. D. van den Brink
2. J. Dudakov
3. A. Hanash

Citations in the corpus

• Interleukin-22: immunobiology and pathology (2015, background): “However, dendritic and T cells seem to play a predominant role and the primary axis seems to be the production of IL-23 and IL12 by dermal myeloid dendritic cells, which subsequently activates Th1, Th17 and Th22 cells to secrete IL-17, IFN-γ, TNF and IL-22 (288).”
• Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1 (2017, background): “inflammatory bowel disease, and uveitis (Duerr et al., 2006; Korn et al., 2009; Lowes et al., 2014; Lubberts, 2015; Murphy et al., 2003).”
• Psoriasis Pathogenesis and the Development of Novel, Targeted Immune Therapies (2017, neutral): “populations found in psoriatic skin.(30) Importantly, the authors also showed that LL-37 expression is upregulated in psoriatic plaques, correlates with disease activity, and results in direct activation of plasmacytoid dendritic cells (pDCs) and myeloid dendritic cells (mDCs) by forming a complex w”