The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells.

By Yi-Hong Hsin, Chunfeng Chen, Shing Huang, T. Shih, P. Lai, P. Chueh. Toxicology Letters, 2008

871 citations recorded by the source corpus.

Subfields: Immunology, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/89d9f1d6a14500cb1089e50f596f2aa0f5e56e01

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In Immunology

1. O. Farokhzad
2. Liying Wang
3. Y. Rojanasakul
4. Amruta Manke

In Materials Chemistry

1. Vyom Sharma
2. A. Dhawan
3. O. Farokhzad
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6. Vinod Yadav
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Citations in the corpus

• Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems (2022, result): “This evidence strongly supports the potential use of AGNPs for cancer chemotherapy [157].”
• Silver nanoparticles: Synthesis, medical applications and biosafety (2020, background): “High levels of ROS can generate damage to DNA double helix in a concentration-dependent manner, including breaking the single or double-stranded DNA, affecting base modifications and DNA cross-links [241, 253, 257].”
• Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549 (2011, background): “It was also reported that apoptosis induced by Ag NPs was mediated by oxidative stress in Wbroblast, muscle, colon and monocyte cell lines (Arora et al. 2008; Foldbjerg et al. 2009; Hsin et al. 2008).”
• Cytotoxicity and genotoxicity of silver nanoparticles in human cells. (2009, background): “Ag-np showed different degrees of in vitro cytotoxicity.(14,24) The cytotoxicity studies were limited by the fact that in most cases the dependence of time of exposure and surface functionalization remained unexplored.”
• Molecular Toxicity Mechanism of Nanosilver (2014, background): “Hsinet al [88]have studied the toxicity mechanism of nanosilver in NIH3T3 fibroblasts.”
• Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity (2013, background): “AgNP activate JNK protein signaling and apoptosis in a variety of cells [50], whereas CeO 2 NP trigger p38 MAPK signaling in bronchoalveolar cells [64].”
• Mechanisms of nanotoxicity: Generation of reactive oxygen species (2014, background): “Hsin et al [89] reported that nano-Ag-induced apoptosis in NIH3T3 cells was mediated by a ROS- and C-Jun-terminal-kinase-dependent mechanism involving the mitochondrial pathway.”
• NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “Several studies have demonstrated that silver NPs are cytotoxic [52–54], but the reports on their ability to promote oxidative stress are conflicting [49,55] and there is a distinct lack of information on their genotoxic potential.”
• Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. (2013, background): “This leads to protein inactivation and induces apoptosis via mitochondrial pathways (Hsin et al., 2008).”
• Toxicity assessment of nanomaterials: methods and challenges (2010, background): “Silver NPs In vitro studies: cytotoxicity and chromosome instability, oxidative stress, apoptosis, intracellular calcium transients, cell cycle arrest, interference with DNA replication fidelity, JNK activation in mammalian cells [108–114]”
• Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles (2016, background): “AgNPs have been found to act through ROS and JNK for induction of apoptosis in NIH3T3 cells (Hsin et al., 2008).”