Cytotoxicity and genotoxicity of silver nanoparticles in human cells.

By O. Farokhzad, R. Langer, P. Asharani, G. Low, K. Mun, M. Hande, S. Valiyaveettil. ACS Nano, 2009

3,601 citations recorded by the source corpus.

Subfields: Materials Chemistry, Pollution

View Paper: https://www.semanticscholar.org/paper/c57a91269a0e5469a37fb39ba6a3ab8c49a18d8a

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In Materials Chemistry

1. Alaaldin M. Alkilany
2. C. Murphy
3. Alexandre Albanese
4. P. S. Tang
5. Vyom Sharma
6. A. Dhawan
7. J. White
8. W. Elmer

In Pollution

1. Vyom Sharma
2. A. Dhawan
3. J. White
4. H. Hamdi
5. Tikam Chand Dakal

Citations in the corpus

• Silver nanoparticles: synthesis, properties, and therapeutic applications (2014, background): “In addition, it has been reported that AgNPs could readily diffuse into, and translocate to, the nucleus through nuclear pore complexes, thereby leading to the formation of ROS, which directly trigger DNA damage and chromosomal abnormalities [41].”
• Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? (2010, positive): “Since gold nanoparticles absorb light in the visible region, their interference with these assays should be considered (AshaRani et al. 2009).”
• The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles (2012, neutral): “In contrast to these studies, no differences have been reported for 10–100 nm silica particles compared to 45 µ m ones, 18 and for nickel ferrite NPs. 19 Okuda-Shimazaki et al demonstrated the importance of the aggregation state and showed that larger aggregates of TiO 2 NPs acted more cytotoxically”
• Silver Nanoparticles as Potential Antiviral Agents (2011, background): “Several studies have demonstrated the cytotoxic effects of metal nanoparticles [90,91,92,93], in fact, silver nanoparticles were found to be highly cytotoxic to mammalian cells based on the assessment of mitochondrial function, membrane leakage of lactate dehydrogenase, and abnormal cell morphologie”
• Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549 (2011, background): “Deposition of Ag NPs has been observed in the nucleus and the nucleolus thereby making the direct interaction between Ag NPs and DNA possible (AshaRani et al. 2009).”
• Antifungal activity of silver nanoparticles against Candida spp. (2009, background): “The already published studies on bactericidal activity have proved that silver NPs kill bacteria at such low concentrations (units of mg/L) [11,14], which do not reveal acute toxic effects on human cells [21,22].”
• Inorganic Nanoparticles in Cancer Therapy (2010, neutral): “(leading to DNA damage) in a dose-dependent fashion (195).”
• The use of polyethyleneimine-modified reduced graphene oxide as a substrate for silver nanoparticles to produce a material with lower cytotoxicity and long-term antibacterial activity (2012, background): “[12] Asharani PV, Mun GLK, Hande MP, Valiyaveettil S.”
• Biosynthesis and characterization of silver nanoparticles using Trichoderma longibrachiatum and their effect on phytopathogenic fungi (2018, background): “Recent studies in mammals and human cells have demonstrated that AgNPs are cytotoxic to various types of cells (Vandebriel et al. 2014; AshaRani et al. 2009).”