Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

By Amruta Manke, Liying Wang, Y. Rojanasakul. BioMed Research International, 2013

1,543 citations recorded by the source corpus.

The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors. The unique physicochemical and electrical properties of engineered nanoparticles (NP) make them highly desirable in a variety of applications. However, these novel properties of NP are fraught with concerns for environmental and occupational exposure. Changes in structural and physicochemical properties of NP can lead to changes in biological activities including ROS generation, one of the most frequently reported NP-associated toxicities. Oxidative stress induced by engineered NP is due to acellular factors such as particle surface, size, composition, and presence of metals, while cellular responses such as mitochondrial respiration, NP-cell interaction, and immune cell activation are responsible for ROS-mediated damage. NP-induced oxidative stress responses are torch bearers for further pathophysiological effects including genotoxicity, inflammation, and fibrosis as demonstrated by activation of associated cell signaling pathways. Since oxidative stress is a key determinant of NP-induced injury, it is necessary to characterize the ROS response resulting from NP. Through physicochemical characterization and understanding of the multiple signaling cascades activated by NP-induced ROS, a systemic toxicity screen with oxidative stress as a predictive model for NP-induced injury can be developed.

Subfields: Health, Toxicology and Mutagenesis, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/fa3d17d6770f82c394613e70ff5114a3e539e0ac

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In Materials Chemistry

1. Anu Kumar
2. Vinod Yadav
3. John Bosco Balaguru Rayappan
4. R. Majumdar
5. Tikam Chand Dakal

Citations in the corpus

• Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles (2016, background): “The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) may be involved in induction of transcriptional activation of antioxidant genes (Manke et al., 2013).”
• A review on detection of heavy metal ions in water – An electrochemical approach (2015, background): “It also decreases the OD levels leading to an oxidative stress and produces ROS [65].”
• 3D bioactive composite scaffolds for bone tissue engineering (2017, background): “Ideally this compressive strength would be complemented by a porosity between 60% and 90% and an average pore size of >150 mm [63,64].”
• Vapors Produced by Electronic Cigarettes and E-Juices with Flavorings Induce Toxicity, Oxidative Stress, and Inflammatory Response in Lung Epithelial Cells and in Mouse Lung (2015, background): “At the nanoscale size, particles may reach the alveolar epithelium and mediate oxidative stress and inflammation [41,42].”