Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

By Rasmus Foldbjerg, D. Dang, H. Autrup. Archives of Toxicology, 2011

782 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/58aa73db7f0b90027feb9596291e500ae6876f35

How researchers see this paper

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In Biomedical Engineering

1. Atish Patel
2. Sang Hun Lee
3. Jingran Lu
4. Bong-Hyun Jun
5. Zhe-Sheng Chen
6. P. Ray
7. Huizhong Xu
8. Liuya Wei

In Materials Chemistry

1. Vyom Sharma
2. A. Dhawan
3. Kenneth A. Dawson
4. Iseult Lynch
5. Atish Patel
6. Sang Hun Lee
7. Jingran Lu
8. B. Reidy

Citations in the corpus

• Silver Nanoparticles: Synthesis and Application for Nanomedicine (2019, background): “The intrinsic cytotoxic property of AgNPs has been applied against various types of cancer cells, such as hepatocellular carcinoma [117], lung [118] and breast cancer [119,120], and cervical carcinoma [121].”
• Silver nanoparticles: synthesis, properties, and therapeutic applications (2014, background): “[69] observed a dose-dependent reduction in mitochondrial function of human alveolar cell line A549 cells.”
• Mechanisms of Silver Nanoparticle Release, Transformation and Toxicity: A Critical Review of Current Knowledge and Recommendations for Future Studies and Applications (2013, methodology): “[63] also used a lung-derived cell line as the most relevant one.”
• Toxicity assessment of nanomaterials: methods and challenges (2010, background): “Silver NPs In vitro studies: cytotoxicity and chromosome instability, oxidative stress, apoptosis, intracellular calcium transients, cell cycle arrest, interference with DNA replication fidelity, JNK activation in mammalian cells [108–114]”
• Mechanisms of nanotoxicity: Generation of reactive oxygen species (2014, background): “These results suggest that nano-Ag induced genotoxicity, mediated by ROS [130].”
• A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives (2017, neutral): “For example, in the A431 cell line, the TT value varied between 1.51 m g/mL and more than 50 m g/mL [76], and in the A549 cell line, the TT value varied from 0.5 m g/mL [77] to 50 m g/mL [76].”