Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

By In-kyung Park, Dalong Qian, M. Kiel, M. Becker, Michael Pihalja, Irving L. Weissman, S. Morrison, M. Clarke. Nature, 2003

2,030 citations recorded by the source corpus.

Subfields: Cell Biology, Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/88322945abab2266d35d038fd6ffc1662df0a448

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. S. Morrison
2. Hans Clevers
3. H. Pasolli
4. Linheng Li
5. A. Trumpp
6. Anne Wilson
7. J. Dick
8. Elaine Fuchs

In Hematology

1. S. Morrison
2. G. Semenza
3. Derrick J. Rossi
4. J. Dick
5. T. Suda
6. Irving L. Weissman
7. A. Trumpp
8. Catriona H. M. Jamieson

In Molecular Biology

1. K. Helin
2. S. Morrison
3. N. Sharpless
4. Hans Clevers
5. A. Bracken
6. Linheng Li
7. M. Clarke
8. Elaine Fuchs

Citations in the corpus

• Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “Several studies show that BMI1 polycomb ring finger oncogene ( BMI1 ) and the Wnt signalling molecule β-catenin regulate the self-renewal of haematopoietic stem cells (HSCs) and the proliferation of leukaemia-initiating cell”
• Applying the principles of stem-cell biology to cancer (2003, background): “Recent studies have supported this concept, showing that specific gene products regulate both the self-renewal of normal somatic stem cells and the proliferation of cancer stem cell”
• Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “Deficient self-renewal was also observed in normal NSCs and leukemia stem cells lacking Bmi1, indicating that Bmi1 is a general regulator of stem cell self-renewal (Park et al., 2003; Lessard and Sauvageau, 2003; Molofsky et al., 2003).”
• Down-regulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells (2009, background): “Bmi1 represses apoptotic, senescence, and differentiation pathways in stem cells (Park et al., 2003).”
• Mechanisms of stem cell self-renewal. (2009, background): “Bmi-1 is one component of polycomb repressor complex 1 that appears to repress p16Ink4a/p19Arf by binding to trimethylated H3K27 at this locus (Bracken et al. 2007, Jacobs et al. 1999, Kotake et al. 2007).”
• Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. (2006, background): “Approximately 90% of NBE cells were positive by immunohistochemical analysis for the NSC markers Nestin, Sox2, and SSEA-1 (Brazel et al., 2005; Capela and Temple, 2002; Lendahl et al., 1990; Park et al., 2003).”
• Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (2005, background): “Inaddition,Bmi-1hasalsobeen shown to play an important role in cell proliferation (Ja-cobs et al., 1999a), stem cell self-renewal (Lessard and Sauvageau, 2003; Park et al., 2003), and cancer (Jacobs et al., 1999b).”
• Evolution of the cancer stem cell model. (2014, background): “…there is still considerable uncertainty as to how stemness is regulated, several regulators including Bmi-1 have been strongly linked to self-renewal and have been implicated in the maintenance of stem cells in several tissues (Lessard and Sauvageau, 2003; Molofsky et al., 2003; Park et al., 2003).”