Evolution of the cancer stem cell model.

By Antonija Krešo, J. Dick. Cell Stem Cell, 2014

2,097 citations recorded by the source corpus.

Genetic analyses have shaped much of our understanding of cancer. However, it is becoming increasingly clear that cancer cells display features of normal tissue organization, where cancer stem cells (CSCs) can drive tumor growth. Although often considered as mutually exclusive models to describe tumor heterogeneity, we propose that the genetic and CSC models of cancer can be harmonized by considering the role of genetic diversity and nongenetic influences in contributing to tumor heterogeneity. We offer an approach to integrating CSCs and cancer genetic data that will guide the field in interpreting past observations and designing future studies.

Subfields: Biomedical Engineering, Control and Systems Engineering, Mechanical Engineering

View Paper: https://www.semanticscholar.org/paper/6bdce5e6c9e7b117a101f07fa62ea1bcc8c702f1

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In Biomedical Engineering

1. Niwen Kong
2. Zena Werb
3. V. Plaks

In Control and Systems Engineering

1. Niwen Kong
2. Zena Werb
3. V. Plaks

In Mechanical Engineering

1. Niwen Kong
2. Zena Werb
3. V. Plaks

Citations in the corpus

• Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “…intratumor heterogeneity: Genomic instability (McGranahan and Swanton 2015), hierarchical organization arising from initiating cancer stem cells (Kreso and Dick 2014), and selective pressure imposed by the immune system likely impact antigen heterogeneity of the tumor (Quail and Joyce 2013).”
• Drug resistance and combating drug resistance in cancer (2019, background): “This genomic heterogeneity of the subpopulations evolves under drug treatment in a Darwinian selection manner, supported by evidence that subclonal compositions differ significantly at different stages of treatment[23,24,101,104].”
• Cancer Evolution: Mathematical Models and Computational Inference (2014, background): “Other important questions concern cancer stem cells (Kreso and Dick 2014).”
• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “They can self-renew their own population and have long-term clone-propagating capacity so they can generate short-lived progeny with self-limited proliferative capacity (Kreso and Dick, 2014).”
• Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma (2016, neutral): “The 100 candidate genes were then restricted to (1) genes that are positively correlated with both PC2 and PC3, which primarily excluded ribosomal protein genes that were only correlated with PC2; (2) genes for which the average relative expression among the stem-like cells was above average.”
• CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. (2018, neutral): “However, specific markers to precisely identify CSCs in vivo are lacking in many tumor types, which poses a great hurdle to target these cells for therapeutic purposes (Kreso and Dick, 2014).”