Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

By R. Cao, Y. Tsukada, Yi Zhang. Molecules and Cells, 2005

928 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2773ea3f4ebc89a07873d60dd476d5ea41146fc5

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Citations in the corpus

Transcriptional regulation by Polycomb group proteins (2013, background): “; and from the Novo Nordisk Foundation, the Danish Cancer Society and the Danish Council for Strategic Research (12-110503) to K.”
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells (2007, methodology): “The specificity of H2Aub1 ChIP was verified using control genes that are targets for PRC1-mediated modification in ES cells ( HoxA7 ; ref”
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. (2012, background): “This prevalent modification can be present at up to 10% of cellular H2A in chromatin as a result of ubiquitination by the E3 ligases present in the Polycomb repressive complex 1 (PRC1) during transcriptional repression (Buchwald et al., 2006; Cao et al., 2005; Li et al., 2006; Wang et al., 2004).”
The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation (2007, background): “However, in contrast to the model that has PRC1 recruitment dependent on its ability to specifically bind H3K27me3 (7, 8, 19), we found that PRC1 recruitment is independent of H3K27me3 on three of the five Cbx8 targets (Pax7, Fgf3, and Fgf4) and on the Bmi1 target (Pax7).”
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. (2006, background): “Recently, the PRC1 complex has been demonstrated to possess a H2A-K119 ubiquitin E3 ligase activity that, like H3K27me3 activity, is associated with the repression of HOX genes (Cao et al. 2005).”
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene (2010, background): “Previous genetic and biochemical studies suggest a hierarchical recruitment model where PRC2mediated H3K27 methylation is required for recruitment of PRC1, which causes H2A-K119 ubiquitination on the Hox gene cluster both in fly and human cells (Wang et al., 2004; Cao et al., 2005).”
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting. (2017, neutral): “Since BMI1 and MEL18 have opposite effects on PRC1 activity (Cao et al., 2005), it is tempting to speculate that the switch of subunits might affect the deposition of the ubiquitin group and therefore gene expression programs.”
Regulation and Cellular Roles of Ubiquitin-specific Deubiquitinating Enzymes (2009, background): “indicate that H2A ubiquitination regulates Hox gene silencing, it is possible that Usp16 may repress Hox gene expression by modulating the levels of uH2A at the promoter and 5′ regulatory region of the Hox gene (83, 153, 174, 175).”
Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells (2009, background): “That said, triMeK27-H3 epigenetic marks are still apparent in Bmi1 null cells (Cao et al., 2005), suggesting that the phenotype does not reflect complete abrogation of PcG-repressive functions.”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “PRC1 complexes have at least two central functions: the first (originally defined for PRC1) is compaction of chromatin, and the second (defined with the BCL6 corepressor, or BCOR, complex) is catalysis of histone H2A monoubiquitination.(62,63) Unlike DNA methylation, polycomb-mediated repression is ”