Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium

By Kyung-ah Kim, M. Kakitani, Jingsong Zhao, T. Oshima, T. Tang, M. Binnerts, Yi Liu, Bryan J. Boyle, E. Park, P. Emtage and 2 more. Science, 2005

594 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/87d3e0751aac2c59136fcda8e522c16e2f94283e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Alexander van Oudenaarden
4. Christof Niehrs
5. Cristina Cruciat
6. K. Loh
7. R. Vries
8. Gad Getz

In Oncology

1. Hans Clevers
2. R. Nusse
3. K. Loh
4. Alexander van Oudenaarden
5. Michael R. Stratton
6. Gad Getz
7. Pengfei Lu

Citations in the corpus

• Prospective derivation of a Living Organoid Biobank of colorectal cancer patients (2015, background): “Indeed, the Wnt agonist R-spondin1 induces dramatic crypt hyperplasia in vivo (Kim et al., 2005).”
• The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations (2011, methodology): “Gain- and loss-offunction manipulation of the canonical Wnt signaling pathway was achieved in mice by using adenoviral expression of the soluble, secreted factors R-Spondin1 (Rspo1) (17, 18) and Dickkopf-1 (Dkk1) (14), respectively.”
• The intestinal crypt, a prototype stem cell compartment. (2013, background): “Indeed, exogenous Rspondin1 induces dramatic crypt hyperplasia (Kim et al., 2005).”
• An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “Reciprocally, the Wnt coagonist R-spondin potently stimulates intestinal proliferation in vivo (30).”
• Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “R-spondin-1 was subsequently shown to potently promote Wnt-dependent intestinal crypt proliferation in vivo (Kim et al., 2005) and in vitro (Sato et al., 2009).”
• The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength (2014, unknown): “The same study confirmed that R-spondin-1 enhances Wnt signal strength, as measured by b -catenin stabilization and phosphorylation of the Wnt/Frizzled coreceptor Lrp6 (Kim et al. 2005).”
• Wnt/beta-catenin signaling in development and disease. (2006, unknown): “Transgenic expression of the Wnt agonist R-spondin-1 results in a massive hyperproliferation of intestinal crypts, confirming this notion (Kim et al., 2005).”