Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.
By Hugo J. G. Snippert, Laurens G. van der Flier, Toshiro Sato, Johan H. van Es, Maaike van den Born, C. Kroon-Veenboer, Nick Barker, Allon M. Klein, J. van Rheenen, Benjamin D. Simons and 1 more. 2010
1,941 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Oncology
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
In Molecular Biology
- Hans Clevers
- F. Doetsch
- V. Silva-Vargas
- Érika Pastrana
- Hugo J. G. Snippert
- C. Bevins
- Nita H. Salzman
- P. Bonaldo
In Oncology
- Hans Clevers
- F. Doetsch
- V. Silva-Vargas
- Érika Pastrana
- Hugo J. G. Snippert
- P. Bonaldo
- F. Gattazzo
- A. Urciuolo
Citations in the corpus
- Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, neutral): “…recombinase is expressed in specific subtypes of neural precursors (reviewed by Dhaliwal and Lagace, 2011), coupled with more versatile reporters, such as the Mosaic Analysis with Double Markers (MADM) (Zong et al., 2005), Confetti (Snippert et al., 2010), and Brainbow systems (Livet et al., 2007).”
- In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics (2011, neutral): “This system can be improved with better Cre-driver lines for more specific targeting of a subtype of precursors and more versatile reporters, such as the Confetti (Snippert et al., 2010) and Brainbow systems (Livet et al., 2007).”
- iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. (2014, neutral): “One limitation of iDISCO is that it is currently incompatible with the original Brainbow and Confetti mice (Livet et al., 2007; Snippert et al., 2010), which provide a rich spectral repertoire of fluorescent signals from multiple fluorescent proteins expressed simultaneously, because antibodies…”
- The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations (2011, methodology): “We also treated Bmi1CreER; Rosa26-Confetti mice with tamoxifen 2 d before 12 Gy irradiation to stochastically label individual Bmi1 ISCs with one of four possible fluorescent colors (4) and trace their fate in response to injury.”
- Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “Lineage tracing experiments have shown that ISCs, rather than dividing asymmetrically to generate daughter cells of different fates, divide symmetrically and adopt stem or transit-amplifying fates in a stochastic manner [162,163].”
- The intestinal crypt, a prototype stem cell compartment. (2013, background): “From short- and long-term clonal tracing data of individual Lgr5hi cells, it has been deduced that stem cells do not divide asymmetrically (Figure 4C) (Lopez-Garcia et al., 2010; Snippert et al., 2010).”
- Type 2 alveolar cells are stem cells in adult lung. (2013, neutral): “Mice were Sftpc-CreER T2 ; Scgb1a1-CreER TM ; and Rosa26R-CAG-tdTm (Rosa-Tm) (13); Rosa26R-CAG-Confetti (Rosa-Confetti ) (19) (supplied by and repair it after injury and to identify the signaling pathways that regulate these behaviors.”
- Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay For Stem Cells (2011, background): “An emerging theme in stem cell biology is that cells can shuttle between quiescent and activated states (Li and Clevers, 2010) and that even more committed progenitors can revert back to a more primitive state (Davies and Fuller, 2008), underscored by the neutral drift that occurs in populations ove”