The intestinal stem cell.

By Nick Barker, M. van de Wetering, Hans Clevers. Genes & Development, 2008

699 citations recorded by the source corpus.

The epithelium of the adult mammalian intestine is in a constant dialog with its underlying mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation, and, ultimately, cell death. The epithelium is shaped into spatially distinct compartments that are dedicated to each of these events. While the intestinal epithelium represents the most vigorously renewing adult tissue in mammals, the stem cells that fuel this self-renewal process have been identified only recently. The unique epithelial anatomy makes the intestinal crypt one of the most accessible models for the study of adult stem cell biology. This review attempts to provide a comprehensive overview of four decades of research on crypt stem cells.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/56c963540682022a4e5d6c3b2be639750308605d

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Citations in the corpus

Mammalian Krüppel-Like Factors in Health and Diseases (2010, background): “Intestinal epithelial homeostasis is regulated by signaling mechanisms that include the Wnt, Notch, Hedgehog, BMP, and PI3K pathways (19, 342, 365).”
Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression (2010, background): “Collective migration has been identified as a critical cellular process particularly during mammary gland branching morphogenesis [16], intestinal epithelial differentiation [17] and wound healing [18].”
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche (2009, background): “1951" language="eng" relation="no"> The surface of the intestine is lined by a simple columnar epithelium that undergoes complete regeneration every 5–7”
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. (2009, background): “With the exception of stem cells and Paneth cells, the intestinal epithelium is renewed approximately every 5 days (Barker et al., 2008).”
Colonocyte metabolism shapes the gut microbiota (2018, background): “Asymmetric cell division of colonic stem cells generates transit-amplifying cells, an early intermediate cell type involved in tissue regeneration that divides a finite number of times until terminally differentiating into various epithelial cell types, including colonocytes, enteroendocrine cells, ”
Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. (2009, background): “Epithelial Renewal as a Major Response to Bacterial Infection Human intestinal cells are continuously replenished by stem cells, the misregulation of which has been implicated in a number of common digestive diseases and cancers (Barker et al., 2008).”