Eating oneself and uninvited guests: autophagy-related pathways in cellular defense.

By Beth Levine. Cell, 2005

840 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/87071553ac639e413209d95d2c25989220190978

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Citations in the corpus

Autophagy as a target for anticancer therapy (2011, background): “Autophagy has an important homeostatic role, mediating the removal of dysfunctional or damaged organelles, which are digested and recycled for cellular metabolic needs”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, neutral): “This process is termed ‘xenophagy’ (26).”
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy (2007, methodology): “The autophagic response requires delivery of the contents sequestered by the autophagosome to the lysosome, whereupon degradation occurs.(13) To verify that Bnip3-induced upregulation of autophagosomes reflected an increase in autophagic activity, and not a build-up of nonfused autophagosomes, we mo”
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. (2006, background): “Autophagy, or type II programmed cell death, is a catabolic process whereby cells self-digest intracellular organelles; however, when allowed to go to completion, autophagy is a means of achieving cell death (Edinger and Thompson, 2003; Levine, 2005).”
Autophagy gene-dependent clearance of apoptotic cells during embryonic development. (2007, background): “One theory is that autophagy may be activated in vivo as a cellular protective mechanism (Levine, 2005) since autophagy genes delay cell death in cultured mammalian cells subjected to starvation or trophic factor withdrawal (Boya et al., 2005; Lum et al., 2005a).”
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. (2008, background): “Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).”
Intracellular staphylococcus aureus: Live-in and let die (2012, positive): “…infections autophagy disposes of leaky vesicles or intracellular bacteria, however, bacterial pathogens have found multiple ways to subvert autophagy (reviewed in Dorn et al., 2002; Kirkegaard et al., 2004; Levine, 2005; Campoy and Colombo, 2009; Orvedahl and Levine, 2009; Ogawa et al., 2011).”
Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. (2006, background): “, 2005), and given the potential importance of autophagy in host responses to pathogens (Deretic, 2005; Levine, 2005), it would be expected that this pathway was also manipulated by viruses.”
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG (2006, background): “UVRAG-mediated activation of the Beclin1–PI(3)KC3 complex promotes autophagy and also suppresses the proliferation and tumorigenicity of human colon cancer cells.”