Intracellular staphylococcus aureus: Live-in and let die

By Martin J. Fraunholz, B. Sinha. 2012

349 citations recorded by the source corpus.

Staphylococcus aureus uses a plethora of virulence factors to accommodate a diversity of niches in its human host. Aside from the classical manifestations of S. aureus-induced diseases, the pathogen also invades and survives within mammalian host cells.The survival strategies of the pathogen are as diverse as strains or host cell types used. S. aureus is able to replicate in the phagosome or freely in the cytoplasm of its host cells. It escapes the phagosome of professional and non-professional phagocytes, subverts autophagy, induces cell death mechanisms such as apoptosis and pyronecrosis, and even can induce anti-apoptotic programs in phagocytes. The focus of this review is to present a guide to recent research outlining the variety of intracellular fates of S. aureus.

Subfields: Infectious Diseases, Molecular Biology, Public Health, Environmental and Occupational Health

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. M. Huemer
2. S. Brugger
3. David L. Paterson
4. Annelies S. Zinkernagel
5. Srikanth Mairpady Shambat

In Molecular Biology

1. M. Huemer
2. S. Brugger
3. Scott A. Beatson
4. David L. Paterson
5. Annelies S. Zinkernagel
6. Srikanth Mairpady Shambat

In Public Health, Environmental and Occupational Health

1. M. Huemer
2. S. Brugger
3. David L. Paterson
4. Annelies S. Zinkernagel
5. Srikanth Mairpady Shambat

Citations in the corpus

• Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “aureus has the capacity to adhere to, enter, and survive within both professional and nonprofessional phagocytes, including macrophages; epithelial, endothelial, and mammary cells; keratinocytes; osteoblasts; and fibroblasts (259, 260).”
• Antibiotic resistance and persistence—Implications for human health and treatment perspectives (2020, positive): “In addition, intracellularly residing S. aureus (Dziewanowska et al , 1999; Jevon et al , 1999; Fraunholz & Sinha, 2012; Lehar et al , 2015) are protected from vancomycin and may be another reason for vancomycin treatment failure.”