Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

By Chengyu Liang, P. Feng, B. Ku, I. Dotan, D. Canaani, B. Oh, Jae U. Jung. Nature Cell Biology, 2006

1,079 citations recorded by the source corpus.

Subfields: Environmental Engineering, Epidemiology

View Paper: https://www.semanticscholar.org/paper/1ef5fb901affe943aa7170d9e0f4fda3f34b89e5

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In Environmental Engineering

1. Beth Levine

In Epidemiology

1. Beth Levine
2. N. Mizushima
3. Guido Kroemer
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Citations in the corpus

• Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “irradiation resistance-associated gene) associates with the Beclin 1Vps34 complex and enhances autophagy [48].”
• Autophagy: process and function. (2007, background): “Another Beclin 1 partner is UVRAG (UV irradiation resistance-associated gene) (Liang et al. 2006), which interacts via the coiled-coil region of Beclin 1.”
• An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “While some data suggest that the UVRAG-associated PtdIns3K complex is involved in autophagosome formation (85), other reports suggest that it may act in later stages of autophagosome development (86).”
• Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages (2009, background): “UVRAG acts as an autophagy-associated protein by binding to Beclin 1 (ref”
• ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase (2013, methodology): “Active GST-ULK1 (1-649) and GST-ULK2 (1-478) from insect cells was purchased from CQuential Solutions (Moraga, CA).”
• Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13 (2011, positive): “Similar to their homologs in yeast, Vps34 in mammalian cells is present in two complexes: Vps34 complex I and Vps34 complex II (Itakura et al., 2008; Liang et al., 2006; Matsunaga et al., 2009; Zhong et al., 2009).”
• Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, background): “, 2011), the PI3KC3-C2 complex (containing UV radiation resistance associated [UVRAG]) (Liang et al., 2006), and the rubicon autophagy regulator (RUBCN)-containing complex (Tabata et al.”
• Autophagy in malignant transformation and cancer progression (2015, positive): “…for the BECN1 activator UV radiation resistance associated (UVRAG) is monoallelically mutated in a high proportion of gastric and colonic tumors (Liang et al , 2006; Kim et al , 2008), and the expression of SH3-domain GRB2-like endophilin B1 (SH3GLB1, a positive modulator of UVRAG best known as…”
• The Beclin 1 network regulates autophagy and apoptosis (2011, positive): “UVRAG directly binds Beclin 1 through the CCD.(40) UVRAG can disrupt the Beclin 1-dimer interface, forming a heterodimer with Beclin 1 (Noble et al.”
• Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis (2007, background): “Recently, it has been shown that UVRAG directly interacts with the Beclin 1–PI(3)KC3 lipid kinase complex to activate autophag”