The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.
By Fiona Pickford, E. Masliah, Markus Britschgi, Kurt M. Lucin, Ramya Narasimhan, Philipp A. Jaeger, Scott A. Small, B. Spencer, E. Rockenstein, Beth Levine and 1 more. Journal of Clinical Investigation, 2008
1,161 citations recorded by the source corpus.
Subfields: Clinical Biochemistry, Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/3fc7cd1c79fb0a6ea1fd693756c6df2b990e451e
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In Clinical Biochemistry
In Epidemiology
- Guido Kroemer
- Guillermo Mariño
- D. Rubinsztein
- Fiona M Menzies
- Angeleen Fleming
- Junying Yuan
- S. Ghavami
- S. Shojaei
In Physiology
- Guido Kroemer
- T. Wyss‐Coray
- A. Andersson
- Guillermo Mariño
- Rute Martins
- S. Stern
- W. Link
- P. Westermark
Citations in the corpus
- The lysosome: from waste bag to potential therapeutic target. (2013, background): “Indeed, the restoration of lysosomal proteolysis and autophagy efficiency in mouse models of Alzheimer’s disease has yielded promising therapeutic effects on neuronal function and cognitive performance (Pickford et al., 2008; Caccamo et al., 2010; Yang et al., 2011; Steele et al., 2012).”
- Autophagy and aging. (2011, background): “…amyloid ß upon transgenic expression of human amyloid precursor protein Aging-related malignancies; neurodegeneration Mathew et al., 2009; Pickford et al., 2008 Bcn1 +/À Central nervous system-specific knockout of Atg5 or Atg7 Progressive accumulation of ubiquitinylated proteins as…”
- Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity (2012, background): “, amyloid beta and alpha synuclein) or damaged mitochondria may be involved [33,75-78].”
- Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “reduced Ab aggregates in APP transgenic mice (Pickford et al., 2008).”
- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “Autophagy may also be affected by reduced levels of beclin 1 mRNA and protein, which have been reported in AD brains (Pickford et al., 2008; Small et al., 2005).”
- Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, positive): “In contrast, beclin-1 (ATG6) level, a key component for autophagosome formation in the autophagy canonical pathway, is reduced in affected brain regions of AD patients (Pickford et al., 2008).”