Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans.

By Claudio Franceschi, M. Capri, Daniela Monti, S. Giunta, F. Olivieri, F. Sevini, M. Panourgia, L. Invidia, L. Celani, M. Scurti and 3 more. Mechanisms of Ageing and Development, 2007

2,034 citations recorded by the source corpus.

Subfields: Aging, General Health Professions, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/86bf0a4ce136c4272c0afdfa21b766f87cb93258

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In Pediatrics, Perinatology and Child Health

Citations in the corpus

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Endothelial NADPH oxidases: which NOX to target in vascular disease? Trends Endocrinol Metab (2014) 25(9):452–63.”
Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis (2015, background): “Aging is associated with low-grade chronic systemic inflammation characterized by an imbalance between inflammatory and anti-inflammatory pathways [87].”
Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “Within the brain, this inflammatory characteristic of aging, referred to as inflammaging (Franceschi et al., 2000; Franceschi et al., 2007), manifests primarily by the chronic activation of perivascular and parenchymal macrophages/microglia expressing proinflammatory cytokines, while the number of…”
Evolution of the immune system in humans from infancy to old age (2015, positive): “Possibly the most critical change in the ageing innate immune system is the increase in pro-inflammatory cytokines IL-1 b , IL-6, IL-18 and TNF a [97].”
Sleep and immune function (2011, background): “Further evidence that prolonged sleep loss is accompanied by enhanced pro-inflammatory activity comes from studies investigating normal ageing and from clinical investigations of patients with chronic sleep disturbances [45, 91, 120].”
Induction of autophagy by spermidine promotes longevity (2009, background): “A recent study proposed that chronic inflammation might be one of the driving forces of human ageing, causing immunosenescenc”
Ageing and the epidemiology of multimorbidity (2014, background): “A component of ageing is the imbalance between inflammatory and anti-inflammatory networks in individuals resulting in a low-grade chronic inflammatory state referred to as “inflammaging” [27].”
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians (2010, background): “In particular, the increase of IL-6 and IL-8, which is expected for these exceptionally old subjects in spite of their reasonably good health status [7,50,51], was linked with an enrichment in Proteobacteria and a decrease in the amount of some butyrate producing bacteria, such as E.”
Inflammaging and 'Garb-aging'. (2017, background): “Accordingly, we hypothesized that what really matters for a healthy and long life is not simply to have low levels of pro-inflammatory compounds but to reach a balance between inflammatory and anti-inflammatory responses [4].”
Inflammatory Networks during Cellular Senescence: Causes and Consequences (2010, background): “For example, although both frail and healthy centenarians often have plasma levels of pro-inflammatory mediators that are higher than young individuals, healthy centenarians often also have increased levels of anti-inflammatory mediators (for example, cortisol and IL-10) and, overall, reduced chroni”
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype (2015, positive): “Therefore, inhibiting mTOR may suppress pro-tumorigenic eﬀects or help to maintain tissue homeostasis by alleviating the chronic, low-grade inflammation observed in aged tissues 45 .”