Evolution of the immune system in humans from infancy to old age
By Anna Katharina Simon, Georg A. Holländer, A. McMichael. Proceedings of the Royal Society of London. Biological Sciences, 2015
1,732 citations recorded by the source corpus.
This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.
Subfields: Genetics, Immunology
View Paper: https://www.semanticscholar.org/paper/8875c1f4a53fc9b10fbc590bbcc6f7f6558bb928
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Citations in the corpus
- The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Thus, the evidence to date indicates that age-associated changes in the gut microbiome parallel fluctuations in immune status (Simon et al., 2015), and this represents an important consideration in studies evaluating human health or when considering microbiota manipulation for prevention or treatmen”
- Ten questions concerning the built environment and mental health (2019, background): “The timing of the exposure has been shown to be important, being probably most beneficial during early childhood, when the immune response system is developing [144,145].”
- Direct Observation of Repeated Infections With Endemic Coronaviruses (2020, background): “Moreover, the majority of the repeated coronavirus infections were found in children, a cohort more vulnerable to infection because of their immature immune system [23], and 26% of the episodes in the repeated infections were co-infections with other respiratory viruses (see Supplementary Table S2).”