Inflammaging and 'Garb-aging'.

By Claudio Franceschi, Paolo Garagnani, G. Vitale, M. Capri, S. Salvioli. Trends in endocrinology and metabolism, 2017

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The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “Thus, other mechanisms, such as the release of damage-associated molecular patterns from neutrophils may accelerate local and systemic inflammation as well as occur during aging (40), making evident the network structure of the involved molecules/markers and propagation mechanisms.”
IL-6 in inflammation, autoimmunity and cancer (2020, background): “Of note, the local low-grade inflammation that characterizes aging is triggered by senescent cells and is intimately related to age-related diseases such as cardiovascular diseases and cancer (5, 291, 292).”
Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? (2018, background): “The innate immune system can also be stimulated by the so-called internal GARBage system (30).”
Inflammation and aging: signaling pathways and intervention therapies (2023, background): “, mitochondrial RNA, misplaced molecules, and cell debris), is a causal inflammatory stimuli that can accelerate inflammaging.(227,228) Certain cytokines, such as IL-1β and IL-6, have clearly emerged as key to promoting inflammaging.”