Plasticity of the Hippocampus: Adaptation to Chronic Stress and Allostatic Load

By Bruce S. McEwen. 2001

944 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Developmental Neuroscience, Social Psychology

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Citations in the corpus

Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “It has been reported that hormones, including corticosteroids, estrogens, and testosterone, regulate neurogenesis and angiogenesis (Louissaint et al., 2002; McEwen, 2001; Saravia et al., 2007); therefore, the age-associated changes in angiogenesis, neuroplasticity, and multipotent progenitor pool th”
Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. (2006, background): “Whereas such research has focused on the hippocampus both as a regulator of the response to stress and as a target of its effects (Jacobson and Sapolsky, 1991; McEwen, 2001), recent evidence suggests that the PFC also plays a role in these contexts.”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “Corticosteroids are released into the blood circulation following the activation of the hypothalamo-pituitary-adrenal (HPA) axis, primarily by stress (351).”
Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression (2005, background): “Circulating glucocorticoids (GCs) are believed to be instrumental in the structural and functional hippocampal changes after chronic stress (Sapolsky et al., 1985; Magarinos et al., 1996; Joëls, 2001; Lucassen et al., 2001; McEwen, 2001).”
Neural Mechanisms of Extinction Learning and Retrieval (2008, background): “spine count in the hippocampus (McEwen, 2001) and mPFC (Radley et al,”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Recent evidence suggests that adult hippocampal neurogenesis is influenced by the HPA axis and that this relationship may provide a functional link between neurogenesis and MDD. Stress-induced reductions in hippocampal volume, morphology and neurogenesis are glucocorticoid-dependent (McEwen, 2001).”
The biopsychosocial approach to chronic pain: scientific advances and future directions. (2007, background): “The negative effects of this stage of the adaptation syndrome include atrophy of muscle tissue, impairment of growth and tissue repair, immune system suppression, and morphological alterations of brain structures, which together might set up conditions for the development and maintenance of a variet”
The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “McEwen BS (2001). Plasticity of the hippocampus: adaptation to chronic stress and allostatic load.”
Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment (2003, result): “Taken together, these findings add to the existing findings on the effects of IS and stress on the brain (McEwen, 2001; Nestler et al, 2002; Stewart and Reid, 2002) and indicates a complex effect of stress on neurogenesis at the longer time points examined.”
Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood (2005, background): “There are a number of models in the literature that suggest long-term negative consequences of increased HPA axis activity on brain function and integrity via the neurotoxic effects of glucocorticoids (Sapolsky et al., 1986; McEwen, 2001).”
Prospective reports of chronic life stress predict decreased grey matter volume in the hippocampus (2007, background): “…and debranching of apical dendrites in CA3 pyramidal neurons, a decrease in the proliferation of new neurons in the dentate gyrus, a decrease in hippocampal cell body size, and a decrease in expressed dendrite spines (Fuchs et al., 2004; Fuchs and Flugge, 1998; McEwen, 1999, 2001; Sapolsky, 2000).”