Prospective reports of chronic life stress predict decreased grey matter volume in the hippocampus

By Peter J. Gianaros, J. Richard Jennings, Lei K. Sheu, Phil J. Greer, Lewis H. Kuller, Karen A. Matthews. NeuroImage, 2007

327 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Social Psychology

View Paper: https://www.semanticscholar.org/paper/7b23bbbac03dcc192fac0773525c04bb01e7c243

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Citations in the corpus

Chronic stress, cognitive functioning and mental health. (2011, unknown): “Similarly, a more recent prospective study reported an association between increased chronic stress over a 20-year period and smaller hippocampal volume and orbitofrontal cortex gray matter (Gianaros et al., 2007).”
Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. (2008, unknown): “Another study, using voxel-based morphometry, has uncovered a relationship between shrinkage of grey matter volume in the hippocampus and orbitofrontal cortex and prospective reports of chronic life stress over a 20 year period (Gianaros et al., 2007).”
Psychological Perspectives on Pathways Linking Socioeconomic Status and Physical Health (2011, background): “…with higher scores on subjective SES, those with lower scores had reduced gray matter volume in the rostral area of the anterior cingulate cortex, a corticolimbic brain region involved in experiencing emotion and regulating cardiovascular reactivity to psychological stress (Gianaros et al. 2007a).”
Allostatic load biomarkers of chronic stress and impact on health and cognition. (2010, background): “Along with studies by Gianaros et al. (2007) on chronic life stress and, as summarized by Sheline (2003) for mood disorders the hippocampus is a sensitive bellweather of delayed effects of chronic stress in both normal and depressed individuals.”
Psychosocial stress reversibly disrupts prefrontal processing and attentional control (2009, methodology): “examined the relation between PSS scores and hippocampal volumes in postmenopausal women and found a reduction in hippocampal gray matter volumes (21), suggesting that stress effects on human brain structure may generalize to other contexts.”
A Review of Adversity, The Amygdala and the Hippocampus: A Consideration of Developmental Timing (2009, unknown): “Even in healthy middle-aged adults, self-reported stress over 12 years in a longitudinal study was associated with decreases in hippocampal grey matter volume acquired at year 13 in women aged 54 years (Gianaros et al., 2007).”
Brain on stress: How the social environment gets under the skin (2012, background): “Moreover, in nondisease conditions such as chronic stress (52), chronic inflammation (53), lack of physical activity (54), and jet lag (55), smaller hippocampal or temporal lobe volumes have been reported.”
More than a feeling: A unified view of stress measurement for population science (2018, background): “In a prospective cohort study of postmenopausal women, higher scores on perceived stress, averaged over nearly two decades, predicted smaller hippocampal grey matter (Gianaros et al., 2007).”
Aerobic Fitness is Associated With Hippocampal Volume in Elderly Humans (2009, unknown): “…by a number of lifestyle and health related factors such as depression (O'Brien et al., 2004), hypertension (Raz et al., 2005), chronic heavy drinking (Beresford et al., 2006), the use of hormone therapy (Erickson et al., 2005), and reports of chronic stress (McEwen, 2006; Gianaros et al., 2007).”
Stress- and Allostasis-Induced Brain Plasticity (2011, unknown): “Among postmenopausal women, for example, higher levels of chronic perceived stress, as measured over an approximate 20-year period of life, have been associated with reduced gray matter volume in the hippocampus and in a region of the lateral prefrontal cortex (19).”