Neural Mechanisms of Extinction Learning and Retrieval

By Gregory J. Quirk, Devin Mueller. Neuropsychopharmacology, 2008

1,590 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/2d207495390d2c6bd1fd045332815854a3d59cb5

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In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

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Citations in the corpus

Optimizing Exposure Therapy for Anxiety Disorders: An Inhibitory Learning and Inhibitory Regulation Approach (2015, background): “Also, it is presumed that the hippocampus creates a unique representation of the context in which extinction took place, and modulates the effect of the PFC on the amygdala [Quirk and Mueller, 2008].”
Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, positive): “The reader is referred to a number of excellent reviews for theoretical and behavioral accounts of fear conditioning and extinction (239, 274, 299, 327, 369, 389, 457), the impact of contextual influences (180, 431), the reconsolidation of fear memories (331), the role of the GABAergic system (105) ”
The Adolescent Brain and the Emergence and Peak of Psychopathology (2015, background): “The amygdala is a medial temporal lobe structure that supports the formation, maintenance, and expression of learned fears, while the vmPFC promotes the regulation and extinction of fear expression (Maren, 2001; Phelps, Delgado, Nearing, & LeDoux, 2004; LeDoux, 2007; Quirk & Mueller, 2008).”
Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear (2010, positive): “Interestingly, we observed that inactivation of IL impaired the acquisition of extinction, which would seem to contradict many previous studies showing that IL lesion or inactivation does not affect the initial learning of extinction (Quirk and Mueller, 2008).”
Memory engrams: Recalling the past and imagining the future (2020, background): “With time after extinction training, CRs often recur (spontaneous recovery) (137, 138), showing that the original fear memory is not erased (139-142).”
Computational models of reinforcement learning: the role of dopamine as a reward signal (2010, background): “Finally, fear conditioning is another well documented conditioning paradigm amenable to extinction studies (reviewed in Ehrlich et al. 2009; Quirk and Mueller 2007).”
Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and Possibilities (2009, background): “Extinction is therefore an active process and not simply a passive, dissipating process of forgetting (Myers and Davis, 2007; Quirk and Mueller, 2008).”
Understanding resilience (2013, background): “the amygdala, hippocampus, medial PFC, nucleus accumbens, ventromedial hypothalamus, and a number of brain stem nuclei (Davis, 2006; Maren, 2008; Quirk and Mueller, 2008).”
The ecology of human fear: survival optimization and the nervous system (2015, background): “In conjunction with the prefrontal cortex, the amygdala may work to cue an individual to environmental signals of interest (Schafer and Moore, 2011).”
The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “…hippocampus, ventromedial hypothalamus, periaqueductal gray, a number of brain stem nuclei, thalamic nuclei, insular cortex, and some prefrontal regions (mainly infralimbic cortex) have been identified in these studies (for recent reviews see Davis, 2006; Maren, 2008; Quirk and Mueller, 2008).”
Prefrontal control of fear: more than just extinction (2010, background): “IL-mediated inhibition of fear after extinction Although previous recording and lesion studies have implicated IL in extinction [9], recent findings have identified specific molecular cascades in IL involved in extinction learning.”
Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness (2012, background): “The new memory trace involves re-consolidated associations of particular contextual stimuli and its previous associations with new stimuli and behavior (Nader et al., 2000; Quirk and Mueller, 2008).”
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress (2012, background): “For a listing of studies implicating vmPFC prior to 2008, see Quirk and Mueller (2008).”
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder (2009, background): “It has been hypothesized that fear extinction and its retention are deficient in PTSD due to failure to activate brain extinction circuitry, including hippocampus and vmPFC (31,42).”
Amygdala inhibitory circuits and the control of fear memory. (2009, background): “Such changes in inhibitory drive could occur in several brain structures, since accumulating evidence points to extinction memory being encoded in a distributed network including the amygdala, hippocampus, and prefrontal cortex (Myers and Davis, 2007; Quirk and Mueller, 2008).”