Sirtuin activators mimic caloric restriction and delay ageing in metazoans

By Jason G. Wood, B. Rogina, Siva Lavu, K. Howitz, S. Helfand, M. Tatar, David A. Sinclair. Nature, 2004

1,876 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/85aa48118fc435809fc5f82c89981f57a969cb39

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Citations in the corpus

FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “In yeast, worms, and flies, expression of Sir2 extends longevity (Kaeberlein et al., 1999; Tissenbaum and Guarente, 2001; Rogina and Helfand, 2004; Wood et al., 2004).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “Additional results showed that resveratrol mimics caloric restriction and delays aging by extending the lifespan of metazoans and yeast (Howitz et al., 2003; Wood et al., 2004).”
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. (2007, background): “Finally, the sir-2 gene has been shown to be important to mediate certain forms of DR in a variety of species from yeast to flies [38–41], though this observation is still subject to debate [24,25,42,43].”
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells (2005, positive): “The Drosophila melanogaster Sir2 gene was also shown to mediate life extension in response to dietary restriction [16,17].”
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. (2006, neutral): “Increased Sir2 activity in C . elegans and Drosophila also extends life span (Tis-senbaum and Guarente, 2001; Wood et al., 2004); however, the mechanism of life span extension seems to differ from that in yeast.”
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. (2011, background): “Several groups havereportedthatresveratrolisabletoincreaselifespanin Drosophila(30,31)andCaenorhabditis elegans(30,32,33), and a short-lived species of fish (34), though others have reportedthatthisagentdidnotincrease lifespanineither of the first two species (35).”
Sirtuins in aging and age-related disease. (2006, background): “1-dependent life-span extension has been observed for resveratrol (Wood et al., 2004).”
AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol (2009, background): “Resveratrol is a natural polyphenolic compound found in grapes and red wine and has been shown to extend lifespan in many organisms, including yeast (1), flies (2), and worms (2–4).”
Overview of caloric restriction and ageing. (2005, background): “Subsequently, the Guarente group and the Sinclair group reported findings indicating that it is likely that sirtuin protein deacetylase activity is involved in CR-induced life extension in invertebrate animal species as well as in mammalian species (Picard et al., 2004; Wood et al., 2004).”
Sirt1 and the Mitochondria (2016, background): “SIR2 and its metazoan orthologues have been prominently associated with lifespan extension (Howitz et al., 2003; Tissenbaum and Guarente, 2001), in particular that induced by caloric or dietary restriction (CR/DR) (Rogina and Helfand, 2004; Wood et al., 2004).”
Target identification using drug affinity responsive target stability (DARTS) (2009, methodology): “3E), as reported previously (14), this longevity effect is lost in eIF4A knockdown worms (Fig.”
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. (2007, background): “*Correspondence: david_sinclair@hms.harvard.edu DOI 10.1016/j.cell.2007.07.035”