Target identification using drug affinity responsive target stability (DARTS)

By Brett Lomenick, Rui Hao, Nao Jonai, R. Chin, M. Aghajan, S. Warburton, Jianing Wang, Raymond P. Wu, Fernando Gomez, J. Loo and 7 more. Proceedings of the National Academy of Sciences of the United States of America, 2009

849 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/08827ee5b59efa8f7091cd83720ab5d9bc5bf27a

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In Molecular Biology

1. R. Su
2. Andre Terzic
3. Jianjun Chen
4. Timothy J. Nelson
5. P. Dzeja
6. C. Folmes
7. Jiangbo W
8. Chuan He

Citations in the corpus

• Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia (2019, methodology): “As shown by Drug Affinity Responsive Target Stability (DARTS) assay (Lomenick et al., 2009), FB23-2 could not Huang et al.”
• Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming (2011, methodology): “Label-free quantitative comparison of SDS-PAGE protein and peptide abundance was carried out on acquired MS spectra using Rosetta Elucidator’s differential workflow, with annotation performed using PeptideTeller and ProteinTeller (Neubert et al., 2008; Lomenick et al., 2009).”
• Targeting FTO suppresses cancer stem cell maintenance and immune evasion (2020, neutral): “(L) Western blot analysis of FTO WT (upper panel) and FTOK216A/S229A/H231A (lower panel) from DARTS with CS2 in MONOMAC 6 cells.”
• Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery (2018, methodology): “This method has been used to validate several target proteins for compounds such as resveratrol and rapamycin [129,131].”