Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

By M. Balazs, F. Martin, T. Zhou, J. Kearney. Immunity, 2002

701 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/85255b9bb1cc1f00073b8a0149a114d1a77ee629

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In Immunology

Citations in the corpus

NF-κB1 p50 Is Required for BLyS Attenuation of Apoptosis but Dispensable for Processing of NF-κB2 p100 to p52 in Quiescent Mature B Cells1 (2003, background): “More recent evidence further suggests that BLyS may augment the T-independent Ab response by prolonging the survival of plasmablasts (11).”
Structure-function of the immune system in the spleen (2019, background): “These bloodderived monocytes, after encountering bacteria in the blood, can exit into the MZ and induce T cell–independent MZB responses (48).”
The follicular versus marginal zone B lymphocyte cell fate decision (2009, background): “These cells express high levels of CD21 and CD1d and respond vigorously to blood borne pathogen”
B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells (2012, background): “More importantly, treatment with Atacicept, which reduces numbers of shortand long-lived plasma cells (Balázs et al., 2002; O’Connor et al., 2004; Belnoue et al., 2008), resulted in aggravation, not improvement, of RR-MS (Hartung and Kieseier, 2010).”
Dendritic cells: translating innate to adaptive immunity. (2006, background): “which DCs interact directly with B cells and may require molecules like BAFF on the DCs [202].”
BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells (2004, background): “However, a recent work implicates BLyS as a regulator of short-lived PC emergence resulting from TI responses within the marginal zone (MZ) of the spleen (15).”
Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “Interestingly, a prior study revealed that neutrophils are one of the major cell types responsible for capturing and transporting circulating bacteria to the splenic marginal zone in mice (Balázs et al., 2002).”
The who, how and where of antigen presentation to B cells (2009, methodology): “Static in vitro imaging approaches have been used to study DC-mediated antigen presentation to splenic marginal-zone B cell”
The regulation of IgA class switching (2008, background): “Subsequent recycling of the endocytosed antigen to the plasma membrane is followed by its presentation to B cell”
Structure and function of the spleen (2005, background): “On entry to the spleen, these DCs mediate the initial differentiation and survival of B cells to become antibody-producing plasmablasts, which occurs in the bridging channel”
B–helper neutrophils stimulate immunoglobulin diversification and production in the marginal zone of the spleen (2011, background): “The role of neutrophils in B cell activation and immunoglobulin production is unknown, but published studies show that these granulocytes home to the MZ in response to blood-borne bacteri”
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. (2003, background): “…and virus stimulation of 4 104 pDCs during 48 hr (one of three experiments). ate into plasma blasts while pDC-derived IL-6 permits BLyS and APRIL, support this hypothesis (Balazs et al., 2002; Litinskiy et al., 2002; MacLennan and Vinuesa,plasma blasts to become antibody-secreting plasma cells.”
TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. (2003, background): “While dendritic cells play central rolesto marginal zone B cells (Balazs et al., 2002).”