TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.

By N. Serbina, T. Salazar-Mather, C. Biron, W. Kuziel, Eric G. Pamer. Immunity, 2003

1,272 citations recorded by the source corpus.

Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals that modulate T cell differentiation. While the role of DCs in adaptive immunity is well established, their involvement in innate immune defenses is less well defined. We have identified a TNF/iNOS-producing (Tip)-DC subset in spleens of Listeria monocytogenes-infected mice that is absent from CCR2-deficient mice. The absence of Tip-DCs results in profound TNF and iNOS deficiencies and an inability to clear primary bacterial infection. CD8 and CD4 T cell responses to L. monocytogenes antigens are preserved in CCR2-deficient mice, indicating that Tip-DCs are not essential for T cell priming. Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/62cddfe816f061d0ad898ee840e74414d8b37b06

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In Immunology

1. Steffen Jung
2. TA Wynn
3. P. Murray
4. F. Geissmann
5. Eric G. Pamer
6. G. Randolph
7. Florent Ginhoux
8. M. Pittet

Citations in the corpus

• Antimicrobial reactive oxygen and nitrogen species: concepts and controversies (2004, background): “Although NO d production has been studied most extensively in macrophages, non-phagocytic cells and a subset of DENDRITIC CELLS”
• Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice (2016, positive): “…U /L un g (lo g1 0) 16 24 48 BALB/c Ifnar-/- **ns ns (legend on next page) 184 Cell Host & Microbe 19, 181–193, February 10, 2016 ª2016 Elsevier Inc. cells expressed CCR2, F4/80, and CD11c, but not Ly6G and Siglec-H, suggesting that they were IMMs (Serbina et al., 2003) (Figure 3C).”
• Predicting Network Activity from High Throughput Metabolomics (2013, background): “It is known that iNOS is induced in dendritic cells by LPS but not by virus [47,61].”
• Repertoire of microglial and macrophage responses after spinal cord injury (2011, background): “Upon subsequent MYD88 signalling, these cells differentiate into tumour necrosis factor (TNFα)- and nitric oxide-producing dendritic cell”
• Skin immune sentinels in health and disease (2009, background): “Dermal DCs that produce both TNF and inducible nitric oxide synthase ( iNOS ) are known as IDCs or TIP (TNF- and iNOS-producing) DC”
• Macrophage activation by endogenous danger signals (2008, background): “In the murine system, they appear to be able to differentiate not only into macrophages but also into inflammatory DCs, including those which can produce TNFα and inducible nitric oxide [9].”
• Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal (2013, background): “They differentiate into inflammatory macrophages and dendritic cells (DCs) that produce tumor necrosis factor (TNF), inducible nitric oxide synthase, and reactive oxygen species in response to bacterial and parasitic infection (Narni-Mancinelli et al., 2011; Robben et al., 2005; Serbina and Pamer, 2”
• Pathogenesis and therapy of psoriasis (2007, background): “In psoriatic lesions, CD11c p DCs express high levels of tumour necrosis factor (TNF) and the enzyme inducible nitric oxide synthase (iNOS), and have been proposed to be the human equivalent of TIP-DCs (TNF- and iNOS-producing DCs), cells that have effector functions in clearing some bacterial infe”
• Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. (2008, background): “Another study of resistance to Listeria infection in mice demonstrated the importance of a TNF/inducible nitric oxide synthase–producing dendritic cell subset in the spleen (Serbina et al., 2003).”
• Steady-state and inflammatory dendritic-cell development (2007, background): “Another example is the DCs that appear after the infection of mice with Listeria monocytogenes”