B–helper neutrophils stimulate immunoglobulin diversification and production in the marginal zone of the spleen
By Irene Puga, M. Cols, C. Barra, B. He, L. Cassis, M. Gentile, L. Comerma, Alejo Chorny, Meimei Shan, Weifeng Xu and 39 more. Nature Immunology, 2011
652 citations recorded by the source corpus.
Neutrophils use immunoglobulins to clear antigen, but their role in immunoglobulin production is unknown. Here we identified neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen. Neutrophils colonized peri-MZ areas after postnatal mucosal colonization by microbes and enhanced their B cell–helper function after receiving reprogramming signals, including interleukin 10 (IL-10), from splenic sinusoidal endothelial cells. Splenic neutrophils induced immunoglobulin class switching, somatic hypermutation and antibody production by activating MZ B cells through a mechanism that involved the cytokines BAFF, APRIL and IL-21. Neutropenic patients had fewer and hypomutated MZ B cells and a lower abundance of preimmune immunoglobulins to T cell–independent antigens, which indicates that neutrophils generate an innate layer of antimicrobial immunoglobulin defense by interacting with MZ B cells.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/150e2517374bb0ec7a206e9bb6daeac278bc28be
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Citations in the corpus
- Neutrophil-Derived Cytokines: Facts Beyond Expression (2014, background): “Accordingly, BAFF and APRIL (other than IL-21 and, possibly, CD40L) have proven to be fundamental mediators of the functions of a recently identified neutrophil subset in human spleen – the so called “Bhelper” neutrophil subset – precisely for their ability to stimulate immunoglobulin diversificatio”
- Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “These aged neutrophils are then cleared from the blood by migration into tissues or by returning to the bone marrow. circulation and influence neutrophil aging (Zhang et al., 2015) and also the development of B cell-helper neutrophils in the spleen (Puga et al., 2011).”