Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6.
By G. Jego, A. Palucka, J. Blanck, Cecile Chalouni, V. Pascual, Jacques Banchereau. Immunity, 2003
1,121 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/fb4756185871a8b438ac2c74f88249cb60c86d2a
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Shizuo Akira
- R. Medzhitov
- Yong‐jun Liu
- Jacques Banchereau
- Bali Pulendran
- Rafi Ahmed
- Taro Kawai
- G. Trinchieri
Citations in the corpus
- Cancer immunotherapy via dendritic cells (2012, positive): “Furthermore, activated pDCs can induce the maturation of activated B cells into plasma cells through both cytokines and surface signallin”
- Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “and, in conjunction with IL-6, drive B cells to differentiate into mature antibody-secreting plasma cell”
- RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement (2005, background): “In addition, IFN- � has been found to have a direct effect on B cell activity by promoting plasmablast differentiation ( 18 ) and specifically upregulating TLR7 and MyD88 expression (19).”
- Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “Activated pDCs might contribute to plasma cell generation as well, because they induce the differentiation of proliferating B cells into plasma cells through IFN and IL-6 (Jego et al., 2003).”
- Plasmacytoid dendritic cells in immunity (2004, background): “A very important aspect of pDC-mediated regulation of adaptive immunity is the ability, through the production of both type I interferons and IL-6, to induce human B cells to differentiate into plasma cells and produce immunoglobuli”
- Immunomodulatory functions of type I interferons (2012, background): “In another study, type I IFNs produced by pDCs, together with IL-6, were also shown to induce plasma cell differentiatio”