Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

By Steffen Massberg, L. Grahl, M. Bruehl, D. Manukyan, S. Pfeiler, C. Goosmann, V. Brinkmann, M. Lorenz, K. Bidzhekov, Avinash B. Khandagale and 9 more. Nature Medicine, 2010

1,208 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/84f9d3de3945d24c908aa0011622eca95226f043

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. C. Rosales
2. C. Jenne
3. A. Mócsai
4. V. Brinkmann
5. N. Mackman
6. Zena Werb
7. M. Egeblad
8. D. Scadden

In Hematology

1. Steffen Massberg
2. Zena Werb
3. A. Mantovani
4. N. Mackman
5. K. Stark
6. M. Egeblad
7. D. Scadden

In Immunology

1. P. Kubes
2. A. Mantovani
3. C. Rosales
4. A. Mócsai
5. K. Martinod
6. D. Wagner
7. S. Jaillon
8. V. Brinkmann

Citations in the corpus

• The Multifaceted Functions of Neutrophils (2013, background): “In addition to the roles of neutrophils in the initiation and progression of atherosclerotic lesions, the chronic presence of neutrophils in these lesions may contribute to thrombosis, myocardial infarction, and stroke, as NET formation and serine protease release promote intravascular thrombus grow”
• Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “NETs can also stimulate the activation of coagulation cascades (Brill et al., 2012) and not only platelet adhesion (Massberg et al., 2010), but also erythrocyte adhesion (Fuchs et al., 2010).”
• Neutrophils in the activation and regulation of innate and adaptive immunity (2011, background): “In addition, TLR4-activated platelets have been shown to bind to adherent neutrophils during sepsis and promote NET formation, which may lead to bacterial trapping but also to endothelial and tissue damage in vitro and in vivo”
• Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “A recent study suggested that neutrophil serine proteases play an important role in the reciprocal coupling between innate immunity and coagulation in mice (Massberg et al., 2010; Fig.”
• Thrombosis: tangled up in NETs. (2014, background): “In this model, the lack of serine proteases in neutrophil elastase/cathepsin G–deficient mice lessens coagulation via reduced TFPI cleavage.(33) Infusion of the anti–H2A-H2B-DNA antibody(55) that neutralizes histones leads to prolonged time to occlusion and lower thrombus stability in the carotid ar”
• Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. (2012, background): “Neutrophil serine proteases have recently been shown to activate coagulation in vivo, including within liver sinusoids, ultimately leading to vascular occlusion (Massberg et al., 2010).”
• Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo (2012, methodology): “Platelets were isolated as described elsewhere (Massberg et al., 2010).”
• Neutrophil extracellular traps in COVID-19. (2020, background): “Simultaneously, serine proteases in NETs dismantle natural brakes on coagulation, such as tissue factor pathway inhibitor and antithrombin (63).”
• Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Although NET generation has been described initially as an antimicrobial mechanism, recent data suggest that NETs could play a more important role in autoimmune and autoinflammatory pathologies, such as vasculitis [71], lung injury [72,73], atherosclerosis [74], rheumatoid arthritis [75,76], thrombo”
• Platelets at the interface of thrombosis, inflammation, and cancer. (2015, background): “The negatively charged nucleobases of theNETs are capable of initiating the contact pathway of coagulation.(40,41) The contactdependent pathway raises circulating thrombin concentrations, which, in turn, increase platelet activation.”
• Atherosclerosis: current pathogenesis and therapeutic options (2011, background): “A link between neutrophils and coagulation has been provided by evidence that neutrophil serine proteases along with externalized nucleosomes promote intravascular thrombus growth in vivo by enhancing tissue factor– and factor XII–dependent coagulation through proteolysis of the tissue factor path”
• Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones (2012, background): “Although elevated amounts of NET were observed in several pathophysiological conditions in vivo [5,22–28] and exaggerated NET formation was correlated with damaging effects and impaired tissue function [29–31], the direct effect of NET and their components on host cells have not been investigated.”